Products for liquid chromatography

FlipLC ™

Samples from natural sources, such as fruits, vegetables, culinary products, water, soil, and bodily fluids, are complex mixtures consisting of multiple compounds. FlipLC method removes impurities from the complex samples, shortens chromatography run time, and increases the lifetime of the columns. It requires minimum sample preparation. The isolation column flips direction and position in the flow path during this process it why we call it FlipLC.


A column with a new outer design.This column and corresponding adapter entirely eliminate the need for any high-pressure fittings or tubing as well as minimizing all possible dead volumes. Furthermore, if a leak ever occurs in the high-pressure column inlet, the mobile phase is contained within the column adapter (no external leakage). Read more.

Cannsep ™

SIELC Technologies has developed a new unique stationary phase based on mixed-mode technology specifically tailored for separation of marijuana cannabinoids.
The columns have different selectivity than any other reverse phase column traditionally used for this analysis. They allows to separate all the active cannabinoids in short run time with common HPLC mobile phase using traditional HPLC equipment.
Read more.


SHARC™ HPLC columns is the latest, innovative column from SIELC Technologies, the inventors of Primesep®.
SHARC™ columns are the first commercially available columns with separation based primarily on hydrogen bonding.

SHARC stands for  Specific Hydrogen-bond Adsorption Resolution Column.
Hydrogen bonding is an interaction (attraction) of bound hydrogen atom to the molecules with electronegative atoms such as oxygen, nitrogen, fluorine.

Primesep ®

Primesep stationary phases offer unprecedented selectivity in the separation of a broad array of chemical compounds and in multiple applications. A wide range of HPLC columns with id’s from 0.5 mm to 22 mm is available. Corresponding Primesep guard columns are available with all stationary phases and do not require holders. SIELC offers a method developmentservice is available for customers. Ask about special custom LC-phases tailored for specific separations.

Obelisc ™

Two complimentary columns, Obelisc R and Obelisc N, based on Liquid Separation Cell ( LiSC ™) technology, offer a new approach to separate a variety of small molecules. Buffer concentration, buffer pH, and organic modifier concentration are three orthogonal parameters of the mobile phase that allow adjustment of column properties to separate complex mixtures.

Promix ™

Promix is an alternative chromatography technology for efficient resolution of peptides and proteins. The technology is based on a combination of two interactions – hydrophobic and ionic. This approach is possible due to a new type of separation media: a chemical combination of hydrophobic and ionic functional groups on a ligand bonded to a silica support. With this phase, unparalleled selectivity and peak capacity can be achieved. Independent adjustment of the amount of buffer and organic modifier creates an infinite number of separation conditions that are suitable for many types of biomolecules.

Legacy ™

SIELC has developed the Legacy column, which can be used in many USP Validated methods.




HPLC Hardware
  • SIELC Technologies is offering a patented design of capillary, analytical, and preparative hardware for HPLC.
  • Unified cylindrical shape of the columns is a signature hardware style developed and produced by SIELC.
  • Superior performance, distinguished look, and reduced hardware costs are just a few benefits of the new design.

SIELC offers a new design of fittings for HPLC. It combines reduced costs, with attractive appearance and premium performance. Two versions of fitting available for high pressure applications up to 5000 psi (350 bar) and ultrahigh pressure applications 14000 psi (1000 bar).
Some benefits of SIELC fittings: finger-tight installation, break-resistant, fully metal thread, improves heat transfer, one-size-fits-most applications, several color options.


Different devices often used in chromatography applications to build special capabilities of the instrumentation. SIELC Technologies is offering several innovative devices:

  • High pressure switching valve
  • HPLC binary pump
  • OEM autosampler
  • UV-Vis detector

Related Journal Articles

Mixed-mode liquid chromatography coupled to tandem mass spectrometry for the analysis of aminoglycosides in meat.

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Coresep Columns

have been transferred to Helix Research Solutions Inc., with further information available at

SIELC Technologies offers a free and fully confidential method development service

to assist you in your column selection and to save you time and money. Samples are screened on up to 6 different phases.

  • Analysis by SIELC’s team of experienced chromatographers
  • Fast turn around
  • Full method details provided
  • LC/MS/ELSD compatible
  • Method scalable to preparative chromatography

Introducing - "Cool Applications" from SIELC

SIELC would like to introduce “Cool Applications” to our customers. These are one-page application notes with minimal wording, showing examples of separations that we consider challenging based on our customer’s feedback, and our overall expertise in the industry. It will take you about 30 seconds to browse it.

We plan to make this a regular event, and we can guarantee that one day you will see applications that can help you with your current project or task.

We are very efficient in developing methods using our mixed-mode technology, and we invite you to become an expert too.
Click on the link here to see our Cool Applications

New Specialty Columns from SIELC

New comprehensive guide for HPLC Method Development

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