Pseudoephedrine is a drug used in cough and cold compositions. One of the preservatives in solutions of pseudoephedrine is citric acid. Both compounds are hydrophilic in nature, with pseudoephedrine being a basic compound and citric acid an acidic compound. Separation of these two compounds is achieved on a Primesep N column. Compounds are separated by combination of HILIC, cation-exchange and anion-exclusion mechanisms. Pseudoephedrine and citric acid are monitored by UV. This HPLC method can be adopted as generic approach for analysis of pseudoephedrine and other hydrophilic drugs and preservatives in mixtures.
Application Column
Primesep C
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsPrimesep N
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsPseudoephedrine (PSE)