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HPLC Application of HPLC Separation of Alendronic, Ibandronic, Etidronic Acids  Dronic acids are bisphosphonates that differ in their alkyl chains. Alendronate (Fosamax) marketed alone is used for osteoporosis and other bone diseases. It is also combined with Vitamin C (Fosavance). A short, 50 mm Primesep SB column separates alendronic, ibandronic, and etidronic acids. The HPLC separation uses a mobile phase of water, acetonitrile (MeCN, ACN), trifluoracetic acid (TFA) or ammonium formate and evaporative light scattering detection (ELSD) with a column temperature of 80C. Application Analytes: Alendronic Acid Ibandronic Acid Etidronic Acid Application Detection: ELSD/MS Detection |
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