Surfynol is non-ionic surfactant which is used in waterborne industrial coatings, internal can coatings, paper coatings, etc. Surfynol 400 nonionic surfactant series’ unique combination of wetting, defoaming and dispersion properties makes them ideal for waterborne packaging ink applications involving indirect food contact. Surfynol 420 provides the best combination of wetting and defoaming. Surfynol 420 is analyzed on Primesep C HPLC column using UV, ELSD and LC/MS compatible conditions. Method can be used for fast and reliable analysis of ionic and non-ionic surfactant and coatings.