Separation of Small Lysine-based Peptide Oligomers

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Short-chain peptides are usually very polar compounds. If the peptide contains lysine moiety it also become very basic in nature. Analysis in traditional reversed-phase of HILIC mode can produce poor peak shape. The method was developed for lysine-based peptide on Primesep AP column in HILIC/cation-exclusion mode. Column can be used for analysis of small peptides with multiple basic groups. Compounds can be monitored by UV, LC/MS or ELSD.



Application Analytes:

Lysine