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HPLC Application of Zn and Na Quantitation in Drug Substances  Primesep 100 allows the quantitation of sodium and zinc cations in a drug product sample. The cations are retained by cation exchange and the drug product is retained by hydrophobic, reversed-phase mechanisms. The separation uses a mobile phase mixture of water, acetonitrile (MeCN, ACN) and trifluoroacetic acid (TFA) with evaporative light scattering detection (ELSD) and UV detection. Application Analytes: Chloride Sodium Zinc Application Detection: UV Detection ELSD/MS Detection |
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