5-Hydroxytryptophan

CAS Number 56-69-9
Molecular Formula C11H12N2O3
Molecular Weight 220.228 g/mol
InChI Key LDCYZAJDBXYCGN-UHFFFAOYSA-N
LogP -1.2
Synonyms
  • 5-Hydroxy-DL-tryptophan
  • 56-69-9
  • 5-hydroxytryptophan
  • DL-5-Hydroxytryptophan
  • 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
  • 114-03-4
  • (+-)-5-Hydroxytryptophan
  • DL-Hydroxytryptophan
  • DL-5-HTP
  • 5-Hydroxytryptophan DL-form
  • DL-Pretonine
  • 5-HTP
  • H-DL-Trp(5-OH)-OH
  • Serotonyl
  • Telesol
  • USAF CB-96
  • Tryptophan, 5-hydroxy-
  • HSDB 4295
  • dl-5-Hydroxytryptophane
  • NCI-C56644
  • 5-Hydroxyl-L-tryptophan
  • D,L-5-hydroxytryptophan
  • EINECS 200-284-8
  • 5-Hydroxytryptophan L form
  • BRN 0088199
  • Quietim
  • Oxyfan

Applications:


HPLC Separation of Polar Compounds





Application Analytes:


Aspartic Acid
Dopamine
Glutamic Acid
Norepinephrine
gamma-Aminobutyric Acid (GABA)

HPLC Separation of Amino Acids in Supplements Composition in Mixed-Mode



Amino acids are essential components of numerous formulation. Health supplements can contain various amino acids and vitamins and require quantitation of each ingredients. Amino acids are very polar compounds with limited or no retention in reversed-phase chromatography. The most common approaches are reversed-phase chromatography with ion-pairing reagent and hydrophilic interaction chromatography (HILIC). Underivatized amino acids can be retained by combination of reversed-phase and cation exchange mechanism on Primesep 100 mixed-mode. Retention time is controlled by amount of acetonitrile, buffer and buffer pH. Method does not require ion-pairing reagent. This method is for UV detection. LC/MS, ELSD or Corona CAD can be employed for analysis of amino acids with trifluoroacteic acid or ammonium formate in the mobile phase. This approach can be used for HPLC analysis of all underivatized amino acids.



Application Analytes:


Amino Acids
Melatonin
Theanine
gamma-Aminobutyric Acid (GABA)