Alginic Acid

CAS Number9005-34-9
Molecular Formula(C6H11NO6)n
Molecular Weight398.317
InChI KeyGKFPPCXIBHQRQT-UHFFFAOYSA-N
LogP-3.7
Synonyms
  • Kaltostat
  • Sodium calcium alginate
  • calginat
  • Kalrostat
  • Vocoloid
  • Xantalgin
  • copper alginate
  • C14H22O13
  • Alloid G
  • Kalrostat 2
  • poly(mannuronic acid)
  • alginic acid, copper salt
  • Alginic acid, calcium salt
  • polymannuronic-guluronic acid
  • Landalgine
  • Nouralgine
  • Pectalgine
  • Amnucol
  • Calginate
  • Callatex
  • Combinace
  • Digamon
  • Duckalgin
  • Halltex
  • Kelcosol
  • Kelsize
  • Keltone
  • Lamitex
  • Manucol
  • Manutex
  • Mosanon
  • Protanal
  • Protatek
  • Protomon
  • Stipine
  • Superloid
  • Tragaya
  • Kelgin
  • Kelgum
  • Kelset
  • Keltex
  • Sazzio
  • Minus
  • Tagat
  • Verdyol Super
  • alginate, sodium
  • Cecalgine TBV
  • Dariloid QH
  • Manutex F
  • Protanal LF

Applications:

HPLC Analysis of Alginic Acid in Heartburn Tablets

July 16, 2009

Alginic acid is a linear copolymer with homopolymeric blocks of (1-4)-linked ?-D-mannuronate (M) and its C-5 epimer ?-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. The monomers can appear in homopolymeric blocks of consecutive G-residues (G-blocks), consecutive M-residues (M-blocks), alternating M and G-residues (MG-blocks), or randomly organized blocks. Molecular weight varies from 10,000 to 600,000. Analysis is a challenging task due to a wide distribution of molecular weights. Alginic acid analyzed in ion-exclusion and size exclusion mode on Primesep C mixed-mode cation exchange column. Alginic acid elutes before void as a single peak with good symmetry. Method can be used for quantitation of alginic acid in various formulation. Low UV or ELSD can be employed.

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Alginic Acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Alginic Acid and Related Products

August 22, 2008

Alginate is used in various pharmaceutical preparations. Chemically, it is a linear copolymer with homopolymeric blocks of (1-4)-linked ?-D-mannuronate (M) and its C-5 epimer ?-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. Alginic acid can be separated from benzoate, citric acid and saccharin by mixed-mode chromatography on Primesep C HPLC column. This method can be used to quantitate alginic acid, citric acid or saccharin in complex mixtures. Various detection technique can be used (UV, ELSD, LC/MS), based on mobile phase selection.

Condition

Column Primesep C, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer Na2HPO4
Flow Rate 0.25 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Acid, Hydrophilic, Ionizable
Analyzing Compounds Alginic acid, Citric acid, Benzoic acid, Saccharin

 

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Alginic Acid
Benzoic Acid
Citric Acid
Saccharin

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.