Compounds  →  Lithium

Separation of Lithium

Reverse Elution Order in Separation of Alkali Cation



Primesep C separates a mixture of inorganic cations, potassium, sodium, and lithium, by a combination of cation exchange and complex formation. The peak order is reversed on the Primesep C column compared to the order normally obtained on columns that rely on cation exchange alone. The mobile phase mixture of water, acetonitrile (MeCN, ACN) and ammonium acetate is compatible with UV and evaporative light scattering detection (ELSD).
Application Analytes:

Lithium
Potassium
Sodium

Application Detection:

ELSD/MS Detection
Complex of Cations on Primesep C is Effected by Organic Modifier



Primesep C separates a mixture of inorganic cations, potassium, sodium, and lithium, by a combination of cation exchange and complex formation. The peak order is reversed on the Primesep C column compared to the order normally obtained on columns that rely on cation exchange alone. In addition, the elution order can be rearranged by simply changing the organic modifier in the mobile phase from acetonitrile to methanol. The mobile phase mixture of water, acetonitrile (MeCN, ACN) or methanol (MeOH) and ammonium acetate is compatible with UV and evaporative light scattering detection (ELSD).
Application Analytes:

Lithium
Potassium
Sodium

Application Detection:

ELSD/MS Detection
Separation of Metal Ions on Primesep 100 Column



Primesep 100 separates the monovalent cations, lithium, potassium, and sodium, and the divalent cations, zinc, manganese, and calcium. The cations are resolved by cation exchange. The mobile phase mixture of water, acetonitrile (MeCN, ACN) and trifluoroacetic acid (TFA) is evaporative light scattering detection (ELSD) compatible.
Application Analytes:

Calcium
Chloride
Lithium
Magnesium
Potassium
Sodium
Zinc

Application Detection:

ELSD/MS Detection
Separation of Sodium, Potassium, Lithium, and Ammonium in Mixed-Mode HPLC


Inorganic cations and ammonia are usually analyzed by ion-exchange chromatography with a conductivity detector. Mixed-mode chromatography achieves the same goal with an ELSD detector. In addition to retaining ions, mixed-mode column can retain hydrophobic molecules also, making it possible to analyze a wide variety of ionic and non-ionic compounds in one run. In this method sodium, potassium, and lithium ions were separated along with ammonium ions on a Primesep 100 column. Detection technique is ELSD.


Application Analytes:

Ammonium Ion
Lithium
Potassium
Sodium

Application Detection:

ELSD/MS Detection
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