m-Xylylenediamine

CAS Number1477-55-0
Molecular FormulaC8H12N2
Molecular Weight136.198
InChI KeyFDLQZKYLHJJBHD-UHFFFAOYSA-N
LogP-0.3
Synonyms
  • m-Xylylenediamine
  • 1477-55-0
  • 1,3-BENZENEDIMETHANAMINE
  • 1,3-Bis(aminomethyl)benzene
  • 1,3-Xylylenediamine
  • 1,3-phenylenedimethanamine
  • m-Xylylendiamin
  • 1,3-Xylenediamine
  • MXDA
  • m-Phenylenebis(methylamine)
  • Methylamine, m-phenylenebis-
  • alpha,alpha'-Diamino-m-xylene
  • 1,3-Bis-aminomethylbenzen
  • m-Xylene-alpha,alpha'-diamine
  • m-Xylylendiamin [Czech]
  • [3-(aminomethyl)phenyl]methanamine
  • m-Xylene-.alpha.,.alpha.'-diamine

Applications:

HPLC Method for Separation of Amines on BIST B and BIST B+ Columns

March 23, 2023

HPLC Method for Separation of Amines on BIST B and BIST B+ Columns by SIELC Technologies

Separation type: Bridge Ion Separation Technology, or BIST™ by SIELC Technologies

HPLC Method for Separation of of Amines on BIST B and BIST B+ Columns by SIELC Technologies
HPLC Method for Separation of Amines on BIST B and BIST B+ Columns by SIELC Technologies

m-Xylylenediamine (MXDA) is a popular curing agent used on epoxy resins. 2,4,6-Tris(dimethylaminomethyl)phenol is another amine-based curing agent used on epoxy resins. Using SIELC’s newly introduced BIST™ method, these amines can be retained and separated on a positively charged, anion-exchange BIST™ B or BIST™ B+ column. The surface chemistry of BIST™ B+ columns are designed to have stronger ionic retention capabilities, resulting in the marked increase in retention compared to BIST™ B columns.

There are two keys to this retention method: 1) a multi-charged, negative buffer, such as Sulfuric acid (H2SO4), which acts as a bridge, linking the positively charged dipeptide to the positively charged column surface and 2) a mobile phase consisting mostly of organic solvent (such as MeCN) to minimize the formation of a solvation layer around the charged analytes. Using this new and unique analysis method, these two amines can be UV detected at 210 nm.

High Performance Liquid Chromatography (HPLC) Method for Analysis of Amines

Condition

ColumnBIST B, 3.2 x 100 mm, 5 µm, 100 A
Mobile PhaseMeCN – 70%
BufferH2SO4 – 0.2%
Flow Rate0.5 ml/min
DetectionUV 210 nm
Peak Retention Time

Description

Class of CompoundsAmines
Analyzing Compoundsm-Xylylenediamine, 2,4,6-Tris(dimethylaminomethyl)phenol

Application Column

BIST B

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A

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BIST B+

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
2,4,6-Tris(dimethylaminomethyl)phenol
m-Xylylenediamine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Separation of Amines in Non Aqueous MP on BIST B+ Column

March 1, 2023

HPLC Method for Separation of of Amines in Non Aqueous MP on BIST B+ by SIELC Technologies

Separation type: Bridge Ion Separation Technology, or BIST™ by SIELC Technologies

HPLC Method for Separation of of Amines in Non Aqueous MP on BIST B+ Column by SIELC Technologies
HPLC Method for Separation of of Amines in Non Aqueous MP on BIST B+ by SIELC Technologies

Dopamine is a key neurotransmitter and medical stimulant used to treat low blood pressure, low heart rate, and heart attacks. m-Xylylenediamine (MXDA) is a popular curing agent used on epoxy resins. 2,4,6-Tris(dimethylaminomethyl)phenol is another amine-based curing agent used on epoxy resins. Using SIELC’s newly introduced BIST method, these 3 amines can be retained on a positively-charged anion-exchange BIST B+ column. There are two keys to this retention method: 1) a multi-charged, negative buffer, such as Sulfuric acid (H2SO4), which acts as a bridge, linking the positively-charged analytes to the positively-charged column surface and 2) a mobile phase consisting mostly of less polar organic solvent (such as IPA) to minimize the formation of a solvation layer around the charged analytes. This method uses an entirely non-aqueous mobile phase to drive BIST retention. The gradient starts with a high concentration of the less polar IPA to generate the initial BIST retention and progresses to the more polar MeOH to elute the longer-retaining amines in a reasonable time. Using this new and unique analysis method, these 3 amines can be retained and UV detected at 210 nm.

High Performance Liquid Chromatography (HPLC) Method for Analysis of of Amines in Non Aqueous MP

Condition

ColumnBIST B+, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseGradient IPA/MeOH- 80/20% to 100% MeOH, 5 min , 5 min hold
BufferH2SO4 – 0.2%
Flow Rate1.0 ml/min
DetectionUV 210 nm
Peak Retention Time3.52 min, 6.12 min, 8.57 min

Description

Class of CompoundsAmines
Analyzing CompoundsDopamine, m-Xylylenediamine, 2,4,6-Tris(dimethylaminomethyl)phenol

Application Column

BIST B+

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
2,4,6-Tris(dimethylaminomethyl)phenol
Dopamine
m-Xylylenediamine

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method For Analysis of Xylylenediamine on BIST B+ Column

June 15, 2022

Separation type: Bridge Ion Separation Technology, or BIST™


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High Performance Liquid Chromatography (HPLC) Method for Analysis of m- Xylylenediamine (MXDA)

HPLC Method for Analysis of m-Xylylenediamine on a BIST B Column.
m-Xylylenediamine (MXDA) is a popular curing agent used on epoxy resins. Using SIELC’s newly introduced BIST method, MXDA, which protonates in water, can be retained on a positively-charged anion-exchange BIST B column. There are two keys to this retention method: 1) a multi-charged, negative buffer, such as Sulfuric acid (H2SO4), which acts as a bridge, linking the positively-charged MXDA analytes to the positively-charged column surface and 2) a mobile phase consisting mostly of organic solvent (such as MeCN) to minimize the formation of a solvation layer around the charged analytes. Using this new and unique analysis method, MXDA can be retained and UV detected at 210 nm.

Condition

Column BIST B+, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 70/30%
Buffer H2SO4 – 0.2 %
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Drug, Basic, Hydrophobic, Ionizable, Zwitterionic
Analyzing Compounds m-Xylylenediamine (MXDA)

 

Application Column

BIST B

BIST™ columns offer a unique and effective way to achieve separations that were traditionally challenging or even impossible with other HPLC columns. With the use of a special mobile phase, these ion exchange columns provide very strong retention for analytes with the same charge polarity as the stationary phase, unlocking new chromatography applications. What makes BIST™ columns stand out is their proprietary surface chemistry, which results in superior selectivity, resolution, and sensitivity. These columns offer a simple, efficient solution for a variety of analytical challenges, making them an excellent choice for researchers and analysts across many different fields. To learn more about the technology that powers BIST™ columns and to explore related applications, check out https://BIST.LC.

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BIST B+

BIST™ columns offer a unique and effective way to achieve separations that were traditionally challenging or even impossible with other HPLC columns. With the use of a special mobile phase, these ion exchange columns provide very strong retention for analytes with the same charge polarity as the stationary phase, unlocking new chromatography applications. What makes BIST™ columns stand out is their proprietary surface chemistry, which results in superior selectivity, resolution, and sensitivity. These columns offer a simple, efficient solution for a variety of analytical challenges, making them an excellent choice for researchers and analysts across many different fields. To learn more about the technology that powers BIST™ columns and to explore related applications, check out https://BIST.LC.

Select options
Application Analytes:
Xylylenediamine
m-Xylylenediamine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of m-Xylylenediamine (MXDA) on BIST™ B+ Column

June 15, 2022

Separation type: Bridge Ion Separation Technology, or BIST™

BIST Ionic Modifier Preparation

High Performance Liquid Chromatography (HPLC) Method for Analysis of m- Xylylenediamine (MXDA)

HPLC Method for Analysis of m-Xylylenediamine on a BIST™ B Column.
m-Xylylenediamine (MXDA) is a popular curing agent used on epoxy resins. Using SIELC’s newly introduced BIST™ method, MXDA, which protonates in water, can be retained on a positively-charged anion-exchange BIST™ B column. There are two keys to this retention method: 1) a multi-charged, negative buffer, such as Sulfuric acid (H2SO4), which acts as a bridge, linking the positively-charged MXDA analytes to the positively-charged column surface and 2) a mobile phase consisting mostly of organic solvent (such as MeCN) to minimize the formation of a solvation layer around the charged analytes. Using this new and unique analysis method, MXDA can be retained and UV detected at 210 nm.

Condition

Column BIST™  B+, 4.6×150 mm,  100A
Mobile Phase MeCN – 80%
Buffer H2SO4 – 0.2%
Flow Rate 1.0 ml/min
Detection UV 210nm

Description

Class of Compounds Amine, Aliphatic amine
Analyzing Compounds m-Xylylenediamine (MXDA)

 

Application Column

BIST B

BIST™ columns offer a unique and effective way to achieve separations that were traditionally challenging or even impossible with other HPLC columns. With the use of a special mobile phase, these ion exchange columns provide very strong retention for analytes with the same charge polarity as the stationary phase, unlocking new chromatography applications. What makes BIST™ columns stand out is their proprietary surface chemistry, which results in superior selectivity, resolution, and sensitivity. These columns offer a simple, efficient solution for a variety of analytical challenges, making them an excellent choice for researchers and analysts across many different fields. To learn more about the technology that powers BIST™ columns and to explore related applications, check out https://BIST.LC.

Select options

BIST B+

BIST™ columns offer a unique and effective way to achieve separations that were traditionally challenging or even impossible with other HPLC columns. With the use of a special mobile phase, these ion exchange columns provide very strong retention for analytes with the same charge polarity as the stationary phase, unlocking new chromatography applications. What makes BIST™ columns stand out is their proprietary surface chemistry, which results in superior selectivity, resolution, and sensitivity. These columns offer a simple, efficient solution for a variety of analytical challenges, making them an excellent choice for researchers and analysts across many different fields. To learn more about the technology that powers BIST™ columns and to explore related applications, check out https://BIST.LC.

Select options
Application Analytes:
m-Xylylenediamine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Analysis of m-Xylylenediamine (MXDA)

February 15, 2012

Condition

Column Primesep AP, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer H2SO4 – 0.2 %
Flow Rate 1.0 ml/min
Detection UV, 215 nm

 

Description

Class of Compounds
Drug, Basic, Hydrophobic, Ionizable, Zwitterionic
Analyzing Compounds m-Xylylenediamine (MXDA)

 

Application Column

Primesep AP

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
MXDA
Xylylenediamine
m-Xylylenediamine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.