Malonic Acid

Malonic Acid structural formula

CAS Number141-82-2
Molecular FormulaC3H4O4
Molecular Weight104.061
InChI KeyOFOBLEOULBTSOW-UHFFFAOYSA-N
LogP-0.810
Synonyms
  • Propanedioic acid
  • 141-82-2
  • Malonic acid
  • 4-02-00-01874
  • 1,3-Propanedioic acid
  • Acide malonique
  • acido malonico
  • Carboxyacetic acid
  • Dicarboxymethane
  • MALONSAEURE
  • Malonsaure
  • Methanedicarboxylic acid
  • NSC 8124
  • BRN 1751370
  • EINECS 205-503-0
  • USAF EK-695
  • UNII-9KX7ZMG0MK
  • Dicarboxylate
  • Dicarboxylic acid
  • H2malo
  • HOOC-CH2-COOH
  • Kyselina malonova
  • Kyselina malonova [czech]
  • Malonate
  • Malonate dicarboxylic acid
  • Metahnedicarboxylic acid
  • Methanedicarbonic acid
  • Propanedioate
  • Propanedioic acid dithallium salt
  • Propanediolic acid
  • Thallium malonate
  • alpha,Omega-dicarboxylic acid
  • 211863-95-5

Applications:

HPLC Separation of Sorbic, Fumaric, Malonic Acids on Newcrom BH Column

June 25, 2020


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Acids with different strengths can be retained and elution order controlled by the use of a mixed-mode column, which has an ion-exchange component in addition to hydrophobic retention.  In this example, the Newcrom BH mixed-mode column was used to separate fumaric, malonic and sorbic acids in HPLC.  Sorbic acid was mostly retained by hydrophobicity, while fumaric and malonic acids were also retained by the adjustment strength of the mobile phase

Condition

Column Newcrom BH, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 20/80%
Buffer H3PO4
Flow Rate 1.0 ml/min
Detection UV 200nm

Description

Class of Compounds Acid
Analyzing Compounds Sorbic Acid, Levulinic Acid

Application Column

Newcrom BH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Fumaric Acid
Malonic Acid
Sorbic acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Methylmalonic and Malonic Acid on Newcrom B Column

November 20, 2019


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HPLC Separation of Methylmalonic and Malonic Acid on Newcrom B Column_1199

Condition

Column Newcrom B, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 10/90%
Buffer H3PO4 – 0.02%
Flow Rate 1.0 ml/min
Detection UV 200nm

Description

Class of Compounds Acid, Hydrophilic, Polar
Analyzing Compounds Methylmalonic acid,  Malonic Acid

Application Column

Newcrom B

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Malonic Acid
Methylmalonic Acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Small Organic Acids on Newcrom B Column

October 22, 2019


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Condition

Column Newcrom B, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 5/95%
Buffer AmAc pH 5.0, Formic Acid
Flow Rate 1.0 ml/min
Detection CAD (Corona) MS- compatible mobile phase

Description

Class of Compounds Acid, Hydrophilic, Ionizable
Analyzing Compounds Glycolic acid, Succinic Acid, Methylmalonic acid, Malic Acid, Maleic Acid, Citric Acid, Tartaric Acid, Fumaric Acid, Malonic Acid

Application Column

Newcrom B

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Citric Acid
Fumaric Acid
Gluconic acid
Glycolic acid
Maleic Acid
Malic Acid
Malonic Acid
Methylmalonic Acid
Succinic Acid
Tartaric Acid
dl-Tartaric acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.