Phthalic Acid

Phthalic Acid structural formula

CAS Number88-99-3
Molecular FormulaC8H6O4
Molecular Weight166.133
InChI KeyXNGIFLGASWRNHJ-UHFFFAOYSA-N
LogP0.73
Synonyms
  • Phthalic acid
  • Benzene-1,2-dicarboxylic acid
  • 1,2-Benzenedicarboxylic acid
  • 88-99-3
  • 1,2-Benzenedicarboxylic acid
  • 4-09-00-03167
  • Acide phtalique
  • acido ftalico
  • NSC 5348
  • o-Benzenedicarboxylic acid
  • o-Carboxybenzoic acid
  • o-Dicarboxybenzene
  • Orthophthalic acid
  • PHTHALSAEURE
  • Phthalsaure
  • Benzene-1,2-dicarboxylic acid
  • BRN 0608199
  • EINECS 201-873-2
  • O-Phthalic acid
  • Kyselina ftalova
  • UNII-6O7F7IX66E
  • Alizarinate
  • Alizarinic acid
  • M 2
  • Naphthalinate
  • Naphthalinic acid
  • O-Benzenedicarboxylate
  • O-Carboxybenzoate
  • Phthalate
  • Phthalinate
  • Phthalinic acid
  • Sunftal 20
  • ortho-phthalic acid
  • 4401-64-3

Applications:

Separation of Phthalic Acids and Related Impurities

July 2, 2013

 

Phthalic acid, phthalic acid isomers, and related products present in the production of phthalic acid were separated on the Primesep D column, based on reversed-phase and in-exchange mechanisms. Neutral, hydrophobic compounds of the phthalic acid production are retained by a reversed-phase mechanism, and phthalic acid and other acidic compounds are retained by a combination of reversed-phase and anion-exchange mechanisms. Resolution and selectivity of this separation can be modified by varying the amount of acetonitrile, buffer concentrations, and buffer pH. This method can be used for monitoring the production cycle of phthalic acid and related impurities.

 

Condition

Column Primesep D, 4.6×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 10-50%, 15 min
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Acid, Hydrophilic, Ionizable
Analyzing Compounds Terephthalaldehyde, Phthalic acid, 4-Carboxybenzaldehyde, Benzoic acid, Terephthalic acid, p –Tolualdehyde, p-Toluic acid

 

Application Column

Primesep D

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
4-Carboxybenzaldehyde
Benzoic Acid
Phthalic Acid
Terephthalaldehyde
Terephthalic Acid
p-Tolualdehyde
p-Toluic Acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Phthalic Acids using Hydrogen Bonding

June 18, 2012

 

Phthalic acid, isophthalic acid and terephthalic acid are all isomers of each other. Being structurally similar, they can present difficulties to reverse-phase HPLC separation. Methods that require high organic concentrations in the mobile phase can cause dewetting in many reverse-phase columns. SHARC 1 column can be operated in anhydrous conditions and uses hydrogen bonding as the mechanism of separation. Here, phthalic acids were separated in pure acetonitrile (ACN), with the ability to adjust retention times by adding methanol (MeOH) to the mobile phase with formic acid and ammonium formate as buffer, making the method MS-compatible. Can also be UV detected at 270nm.

Condition

Column Sharc 1, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN/MeOH
Buffer AmFm, Formic acid
Flow Rate 1.0 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements
Analyzing Compounds Phthalic acid, Terephthalic acid, Isophthalic acid

 

Application Column

SHARC 1

The SHARC™ family of innovative columns represents the first commercially available columns primarily utilizing separation based on hydrogen bonding. SHARC stands for Specific Hydrogen-bond Adsorption Resolution Column. Hydrogen bonding involves an interaction or attraction between a bound hydrogen atom and molecules containing electronegative atoms, such as oxygen, nitrogen, and fluorine.

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Application Analytes:
Isophthalic acid
Phthalic Acid
Terephthalic Acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Organics Acids

November 21, 2006

Primesep D separates organic acids such as fumaric, benzoic, phthalic, naphthoic, and maleic acids by a mixture of anion exchange and reversed phase. Retention times and elution order can be changed by adjusting the percentage of acetonitrile in the mobile. This can not be done by traditional ion-exchange and ion-exclusion chromatography. The HPLC separation uses a mobile phase of water, acetonitrile (MeCN, ACN) and trifluoroacetic acid (TFA) and UV detection at 250 nm.

Condition

Column Primesep D, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer AmFm
Flow Rate 1.0 ml/min
Detection UV 250 nm

 

Description

Class of Compounds
Acid, Hydrophilic, Ionizable
Analyzing Compounds Fumaric Acid, Benzoic Acid, Phthalic Acid, Maleic Acid, Naphtoic Acid

 

Application Column

Primesep D

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Benzoic Acid
Fumaric Acid
Maleic Acid
Naphthoic Acid
Organic Acids
Phthalic Acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Diacid Hydrophobic and Ion Exchange Modes

October 11, 2005

Primesep B combines a hydrophobic, reversed-phase mechanism with ion exchange to separate the diacids, fumaric, benzoic, phthalic, naphthoic, and maleic acids. Changing the acetonitrile content of the mobile phase reverses the peak order for naphthoic and maleic acids. Primesep B combines reversed-phase and anion-exchange mechanism with a mobile phase of water, acetonitrile (MeCN, ACN) and trifluoracetic acid (TFA) and UV detection at 250 nm.

Condition

Column Primesep B, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer TFA
Flow Rate 1.0 ml/min
Detection UV, 250 nm

 

Description

Class of Compounds
Acid, Hydrophilic, Ionizable
Analyzing Compounds Fumaric acid, Benzoic acid, Phthalic acid, Naphthoic acid, Maleic acid, )

 

Application Column

Primesep B

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Benzoic Acid
Dicarboxylic Acids
Fumaric Acid
Maleic Acid
Naphthoic Acid
Phthalic Acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.