Ribavirin

88

CAS Number36791-04-5
Molecular FormulaC8H12N4O5
Molecular Weight244.207
InChI KeyIWUCXVSUMQZMFG-AFCXAGJDSA-N
Synonyms
  • Ribavirin
  • 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
  • 1H-1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl-
  • 1H-1,2,4-Triazole-3-carboxamide, 1-?-D-ribofuranosyl-
  • 1-?-D-Ribofuranosyl-1,2,4-triazol-3-carboxyamide
  • 1-?-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
  • Copegus
  • MegaRibavirin
  • NSC 163039
  • Ravanex
  • Rebetol
  • Ribamide
  • Ribamidil
  • Ribasphere
  • Ribavarin
  • Tribavirin
  • Viramid
  • Virazole
  • Virizadole
  • BRN 0892462
  • Ribamidyl
  • 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
  • Varazid
  • Ribavirin Capsules
  • Ribavirina
  • Ribavirine
  • Ribavirinum

Applications:

HPLC Separation of Ritonavir and Ribavirin

August 22, 2008

Separation type: Liquid Chromatography HILIC

Ritonavir and Ribavarin are two drugs which are very different in their properties for HPLC separation. Very hydrophobic and very hydrophilic drugs are separated on Primesep N using Hydrophilic Interaction Chromatography (HILIC). Ritonavir is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS. Ritonavir is very hydrophobic and non-ionizable and retains very long in reverse phase chromatography. Ribavirin is an anti-viral drug which is active against a number of DNA and RNA viruses. It is a member of the nucleoside antimetabolite drug, which makes it very hydrophilic.

Condition
Column Primesep N, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 97/3%
Buffer No
Flow Rate 1.0 ml/min
Detection UV 250 nm,  MS- compatible mobile phase

Description
Class of Compounds Drug
Analyzing Compounds Ritonavir,  Ribavirin

Application Column

Primesep N

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Ribavirin
Ritonavir
Application Detection:
UV Detection
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