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For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

Sulfamic acid is inorganic acid which is used in various synthesis and compositions. It is used as precursor in synthesis of artificial sweeteners. Sulfamic acid (amidosulfonic acid, amidosulfuric acid, aminosulfonic acid, and sulfamidic acid) is very hydrophilic in nature and does not retain on reversed-phase columns. Acidic nature of this acid allows to retain this compound by mixed-mode mechanism. In current method sulfamic acid is retained by anion-exchange mechanism on Primesep SB mixed-mode anion-exchange column. Method employes acetonitrile and ammonium formate or formic acid. Sulfamic acid has no UV activity and needs to be detected by LC/MS, ELSD or Corona CAD. Retention time of sulfamic acid can be adjusted by the amount of buffer/acid in the mobile phase. This method can be used for analysis of organic and inorganic acids in different sample matrices.

Sulfuric acid (sulfate ions) and sulfamic acid are analyzed in HILIC mode on Primesep N column. Both compounds are hydrophilic in nature and lack UV activity. Compounds are retained by hydrophilic interaction mechanism. Sulfate ion and sulfamic acid are monitored by ELSD. Method can be used for analysis of other inorganic ions.