Terbutaline

CAS Number	23031-25-6
Molecular Formula	C12H19NO3
Molecular Weight	225.288
InChI Key	XWTYSIMOBUGWOL-UHFFFAOYSA-N
LogP	0.9
Synonyms	Terbutaline 5-[2-(tert-Butylamino)-1-hydroxyethyl]benzene-1,3-diol 1,3-Benzenediol, 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]- 23031-25-6 1,3-Benzenediol, 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]- (.+-.)-Terbutaline 1-(3, 5-Dihydroxyphenyl)-2-(t-butylamino) ethanol 1-(3,5-Dihydroxyphenyl)-2-(tert-butylamino)ethanol 5-[2-(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol AR-D 080301 Benzyl alcohol, α-[(tert-butylamino)methyl]-3,5-dihydroxy- Bricanyl Bricaril Terbutalin terbutalino BRN 2370513 5-(2-((1,1-Dimethylethyl)amino)-1-hydroxyethyl)-1,3-benzenediol EINECS 245-385-8 Terbutalina Terbutalinum UNII-N8ONU3L3PG

Applications:

HPLC Method for Separation of Terbutaline Sulfate, Guaifenesin and Ambroxol on Primesep 200 Column

January 12, 2023

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High Performance Liquid Chromatography (HPLC) Method for Separation of Terbutaline Sulfate, Guaifenesin and Ambroxol on Primesep 200 by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Separation of Terbutaline Sulfate, Guaifenesin and Ambroxol on Primesep 200 Column by SIELC Technologies

Terbutaline Sulfate is a β₂ analyst typically used as a prescription-strength cough suppressant. Guaifenesin, also known as Glyceryl Guaiacolate, is a popular expectorant used to treat chest congestion. Ambroxol is a well-known expectorant that targets and breaks down phlegm. Together, these three medicinal compounds are typically found as the active ingredients in many cough syrups. They can be retained, analyzed, and separated on a Primesep 200 mixed-mode column using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and a Phosphoric acid (H3PO4) ionic modifier. This analysis method can be detected in the low UV regime at 210 nm.

High Performance Liquid Chromatography (HPLC) Method for Separation of Terbutaline Sulfate, Guaifenesin and Ambroxol

Condition

Column	Primesep 200, 4.6×150 mm, 5 µm, 100A
Mobile Phase	MeCN/H2O – 30/70%
Buffer	H3PO4 – 0.05%
Flow Rate	1.0 ml/min
Detection	UV 210 nm
Peak Retention Time	2.09, 3.28, 5.81 min

Description

Class of Compounds	Drugs
Analyzing Compounds	Terbutaline Sulfate, Guaifenesin and Ambroxol

Application Column

Primesep 200

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Ambroxol Hydrochloride
Guaifenesin
Terbutaline

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.