Tetrabutylammonium

CAS Number10549-76-5
Molecular FormulaC16H36N
Molecular Weight242.470
InChI KeyDZLFLBLQUQXARW-UHFFFAOYSA-N
LogP1.04
Synonyms
  • Tetrabutylammonium
  • N,N,N-Tributylbutan-1-aminium
  • 1-Butanaminium, N,N,N-tributyl-
  • 10549-76-5
  • Tetrabutylammonium chloride
  • UNII-CBU2X6BBJR
  • TETRABUTYLAMMONIUM ION

Applications:

Separation of Sodium, Tetramethylammonium and Tetrabutylammonium on Primesep 200 Column

July 7, 2011

chr_300.gif

chr_301.gif

Hydrophilic and hydrophobic quaternary amines, along with sodium ion, were separated by mixed-mode chromatography on a Primesep 200 column. Mechanism of retention for sodium and tetramethylammonium ions is cation exchange, while the tetrabutylammonium ion is retained by combination of reversed-phase and cation-exchange mechanisms. All three compounds are not UV-active and monitoring is done by ELSD/CAD.

Condition

Column Primesep 200,  4.6×100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer AmAc pH4.0
Flow Rate 1.0 ml/min
Detection ELSD

 

Description

Class of Compounds
Ions,  Hydrophilic, Ionizable, Quaternary amines
Analyzing Compounds Sodium, Chloride, Tetramethylammonium,  Tetrabutylammonium

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Sodium
Tetrabutylammonium
Tetramethylammonium

Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Quaternary Amines by Reverse-Phase Mechanism

January 16, 2004

Primesep B separates quaternary amines, such as t-butylamine with symmetrical peak shape by a combination of reversed-phase and ion-exclusion mechanisms. The embedded basic functional group on the stationary phase shields the underlying silanols to prevent peak tailing. Excellent peak shape results with a mass spec compatible mobile phase of water, acetonitrile (MeCN, ACN) and trifluoracetic acid (TFA) with evaporative light scattering detection (ELSD).

Condition

Column Primesep B,  4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer TFA
Flow Rate 1.0 ml/min
Detection ELSD

 

Description

Class of Compounds
Ions,  Hydrophilic, Ionizable, Quaternary amines
Analyzing Compounds t-butylamine

Application Column

Primesep B

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Tetrabutylammonium

Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.