Amphetamine sulfate

Amphetamine sulfate structural formula

CAS Number60-13-9
Molecular FormulaC18H28N2O4S
Molecular Weight368.490
InChI KeyPYHRZPFZZDCOPH-UHFFFAOYSA-N
LogP1.81
Synonyms
  • Amphetamine sulfate
  • Sulfuric acid--1-phenylpropan-2-amine (1/2)
  • Benzeneethanamine, alpha-methyl-, sulfate (2:1)
  • 60-13-9
  • DL-Amphetamine sulfate
  • Adiparthrol
  • Aktedrin
  • Alentol
  • (+-)-2-Amino-1-phenylpropane sulfate
  • Amphoids-S
  • Astedin
  • Benzafinyl
  • Benzedrine sulfate
  • Benzies
  • Benzpropamine
  • Betafen
  • Betaphen
  • Bluzedrin
  • Cartwheels
  • Centramina
  • Dietamine
  • Durophet
  • EINECS 200-457-8
  • Euphobine
  • Euphodine
  • Euphodyn
  • Fabedrine
  • Fenedrin
  • Fenopromin sulfate
  • Halloo-wach
  • Ibiozedrine
  • Leodrin
  • alpha-Methylphenethylamine sulfate, (+-)-
  • Mimetina
  • Monetamine
  • NCI-C55710
  • NSC 170999
  • Oraldrina
  • Peaches
  • Penamine
  • Pharmamedrine
  • Phenamine sulfate
  • Phenisopropylamine sulfate
  • Phenopromin
  • Phenpromin
  • Psychedrinum
  • Psychedryna
  • Psychoton
  • Racephen
  • Sedolin
  • Simpamina
  • Simpamine
  • Stimulan
  • Sympametin
  • Synsatedrine
  • Theptine
  • Vapedrine
  • Zedrine
  • 1-Phenyl-2-aminopropane sulfate
  • dl-alpha-Methylphenethylamine sulfate
  • dl-Amphetamine sulphate
  • Razemisches phenylaminopropansulfat
  • UNII-6DPV8NK46S
  • (+-)-Amphetamine sulfate
  • (+-)-Phenisopropylamine sulfate
  • (+-)-alpha-Methylphenethylamine sulfate (2:1)
  • Amphamine sulfate
  • Amphetamine sulphate
  • Amphetamini sulfas
  • Amphetaminium sulfuricum
  • DL-1-Phenyl-2-aminopropane sulfate
  • DL-Amphetamine hydrogen sulfate
  • Desoxynorephedrine sulfate
  • dl-Phenamine sulfate
  • phenaminum

Applications:

Separation of Amphetamine sulfate on Newcrom R1 HPLC column

February 16, 2018
Separation of Amphetamine sulfate on Newcrom C18 HPLC column

Amphetamine sulfate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Amphetamine sulfate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.

HPLC Method for Analysis of Amphetamine

May 10, 2016

88

Amphetamine is a drug that stimulates the central nervous system. It is used to treat ADD, narcolepsy, and obesity. Amphetamine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.

 

Condition

Column Primesep 200, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN – 40%
Buffer H3PO4 – 0.1%,
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
Drug,  Acid, Hydrophilic, Ionizable, Supplements
Analyzing Compounds Amphetamine

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Amphetamine
Amphetamine sulfate

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.