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Application Notes:
Application Columns:
- Primesep® 500 is a mixed-mode HPLC column with general hydrophobic and ion-exchange properties. The Primesep 500 stationary phase combines a hydrophobic chain and a weak carboxylic acid functional group with a pKa of 5 as a cation exchanger. Acids, bases, and neutrals can be retained and separated by Primesep 500 columns. Primesep 500 retains hydrophobic compounds by reversed-phase retention alone or a combination of reversed-phase and ion-exchange retention. Primesep 500 retains basic compounds by reversed phase at mobile phase pH < 5 and separates acids by anion exclusion at mobile phase pH > 5. Methods can be developed on Primesep columns that are fully compatible with detectors such as UV, RI, conductivity, fluorescence, evaporative light scattering (ELSD) as well as mass spectrometers (LC/MS) and preparative chromatography (prep HPLC) systems.
Application Analytes:
Application Detection:
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