Atenolol

Atenolol structural formula

CAS Number29122-68-7
Molecular FormulaC14H22N2O3
Molecular Weight266.342
InChI KeyMETKIMKYRPQLGS-UHFFFAOYSA-N
LogP0.16
Synonyms
  • Atenolol
  • 2-(4-{2-Hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide
  • Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
  • 29122-68-7
  • Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
  • (.+-.)-Atenolol
  • (RS)-Atenolol
  • 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
  • Acetamide, 2-[p-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]-
  • Anselol
  • Antipressan
  • Apo-Atenolol
  • Atcardil
  • Atecard
  • AteHexal
  • Atenblock
  • Atendol
  • Atereal
  • Atolmin
  • Betablok
  • Betacard
  • Blokium
  • Catenol
  • Catenolol
  • Coratol
  • Corotenol
  • Cuxanorm
  • DL-Atenolol
  • Duraatenolol
  • Evitocor
  • Farnormin
  • Felo-Bits
  • Hypoten
  • Ibinolo
  • Internolol
  • Lotenal
  • Myocord
  • Normalol
  • Normiten
  • Novaten
  • Premorine
  • Prenolol
  • Prenormine
  • Seles Beta
  • Selobloc
  • Stermin
  • Tenidon
  • Teno-basan
  • Tenoblock
  • Tenolin
  • Tenolol
  • Tenoprin
  • Tenordin
  • Tenormin
  • Tenormine
  • Tensimin
  • Ternomin
  • Vascoten
  • Vericordin
  • Wesipin
  • BRN 2739235
  • 1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol
  • EINECS 249-451-7
  • Tenobloc
  • Atenol Gador
  • Atenol-Mepha
  • Blocotenol
  • 2-(4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl)acetamid
  • Atenololum
  • UNII-50VV3VW0TI
  • EINECS 262-544-7
  • 2-(p-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
  • 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide
  • Aircrit
  • Alinor
  • Altol
  • Atenet
  • Ateni
  • Atenil
  • Atenol 1A pharma
  • Atenol AL
  • Atenol Atid
  • Atenol Cophar
  • Atenol Fecofar
  • Atenol GNR
  • Atenol Gador
  • Atenol Genericon
  • Atenol Heumann
  • Atenol MSD
  • Atenol NM Pharma
  • Atenol Nordic
  • Atenol PB
  • Atenol Quesada
  • Atenol Stada
  • Atenol Tika
  • Atenol Trom
  • Atenol acis
  • Atenol ct
  • Atenol von ct
  • Atenol-Mepha
  • Atenol-Wolff
  • Atenol-ratiopharm
  • Atenolin
  • Atenolol (JAN/USP)
  • Atenolol [USAN:BAN:INN:JAN]
  • Atenololum [INN-Latin]
  • Atenomel
  • Aterol
  • Betasyn
  • Betatop Ge
  • Blocotenol
  • Cardaxen
  • Cardiopress
  • Duratenol
  • Hipres
  • Jenatenol
  • Juvental
  • Lo-ten
  • Loten
  • Myocord
  • Noten
  • Oraday
  • Ormidol
  • Panapres
  • Plenacor
  • Prinorm
  • Scheinpharm Atenol
  • Serten
  • Servitenol
  • Tenobloc
  • Tenoretic
  • Tenormine [French]
  • Tredol
  • Unibloc
  • Uniloc
  • Xaten

Applications:

Application USP Methods for the Analysis of Atenolol using the Legacy L1 Column

February 20, 2019

Application USP Methods for the Analysis of Atenolol using the Legacy L1 Column

Application Column

SIELC Legacy L1 HPLC column

Legacy L1

SIELC's family of Legacy columns is based on the United States Pharmacopeia's (USP) published chromatographic methods and procedures. Numerous brands have columns used in USP reference standards and methods. USP has created various designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties, allowing you to easily replace older columns that are no longer available without needing to significantly modify your method or SOPs.

Select options
Application Analytes:
Atenolol
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Atenolol

May 10, 2016

45




Atenolol a cardioselective beta-1 adrenergic blocker as well as a synthetic isopropylamino-propanol derivative. It belongs to a class of drugs known as beta blockers and is used to treat high blood pressure (hypertension). Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Meclizine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Atenolol

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Atenolol on Legacy L1 Column

July 2, 2013

Atenolol is a selective beta receptor antagonist, a drug belonging to beta blockers. The USP method was reproduced on the L1 column. This method can be used for the analysis of atenolol by reversed-phase chromatography on a typical C18 HPLC column. Column and method can be used for other drug substances, intermediates and impurities which need to be analyzed according to the United States Pharmacopeia.

Application Notes: Atenolol is a beta blocker used to treat heart disease as well as thyroid disorders and alcohol withdrawal. The USP HPLC method for the separation of atenolol was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS.

Condition

Column Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN
Buffer Octanesulfonic Acid, Sulfuric Acid
Flow Rate 1.0 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
Drug, Beta blocker, Hydrophobic, Ionizable
Analyzing Compounds Atenolol

 

Application Column

SIELC Legacy L1 HPLC column

Legacy L1

SIELC's family of Legacy columns is based on the United States Pharmacopeia's (USP) published chromatographic methods and procedures. Numerous brands have columns used in USP reference standards and methods. USP has created various designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties, allowing you to easily replace older columns that are no longer available without needing to significantly modify your method or SOPs.

Select options

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Atenolol

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.