| CAS Number | 79-08-3 |
|---|---|
| Molecular Formula | C2H3BrO2 |
| Molecular Weight | 138.948 |
| InChI Key | KDPAWGWELVVRCH-UHFFFAOYSA-N |
| LogP | 0.41 |
| Synonyms |
|
Applications:
HPLC Separation of Bromoacetic and Chloroacetic acids on Newcrom B Column
September 10, 2020
HPLC Method for Bromoacetic acid, Dibromoacetic acid, Dichloroacetic acid, Trichloroacetic acid on Newcrom B by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Bromoacetic acid, Dibromoacetic acid, Dichloroacetic acid, Trichloroacetic acid.
Bromo– and chloro– acetic acids are widely used in organic chemistry. Their similar structure makes the acids difficult to retain and separate on reverse-phase HPLC columns. By using Newcrom BH mixed-mode column which also has ion-exchange properties, the separation can be achieved with a simple isocratic method and relatively short time with a mobile phase of acetonitrile (ACN), water and sulfuric acid (H2SO4) buffer.
| Column | Newcrom B, 4.6 x 150 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H2O – 10/90% |
| Buffer | AmFm pH 3.0 |
| Flow Rate | 1.0 ml/min |
| Detection | CAD |
| Class of Compounds | Acid |
| Analyzing Compounds | Bromoacetic acid, Dibromoacetic acid, Dichloroacetic acid, Trichloroacetic acid |
Application Column
Newcrom B
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Dibromoacetic acid
Dichloroacetic acid
Trichloroacetic acid
HPLC Separation of Bromoacetic and Chloroacetic Acids on Newcrom BH Column
June 17, 2020
HPLC Method for Difluoroacetic acid, Dichloroacetic acid, Dibromoacetic acid, Acetic Acid, Bromoacetic acid, Chloroacetic acid, Bromochloroacetic acid on Newcrom BH by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Difluoroacetic acid, Dichloroacetic acid, Dibromoacetic acid, Acetic Acid, Bromoacetic acid, Chloroacetic acid, Bromochloroacetic acid.
Acetic acid and its various chloro- and bromo- forms are widely used in organic chemistry. Their similar structure makes the acids difficult to retain and separate on reverse-phase HPLC columns. By using Newcrom BH mixed-mode column which also has ion-exchange properties, the separation can be achieved with a simple isocratic method and relatively short time with a mobile phase of acetonitrile (ACN), water and sulfuric acid (H2SO4) buffer. UV detection at 200nm.
| Column | Newcrom BH, 4.6 x 150 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H2O – 10/90% |
| Buffer | H2SO4 – 0.3% |
| Flow Rate | 1.0 ml/min |
| Detection | UV 200nm |
| Class of Compounds | Acid |
| Analyzing Compounds | Difluoroacetic acid, Dichloroacetic acid, Dibromoacetic acid, Acetic Acid, Bromoacetic acid, Chloroacetic acid, Bromochloroacetic acid |
Application Column
Newcrom BH
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Bromoacetic acid
Bromochloroacetic acid
Chloroacetic acid
Dibromoacetic acid
Dichloroacetic acid
Difluoroacetic acid
Separation of Bromoacetic acid on Newcrom R1 HPLC column
February 19, 2018
Bromoacetic acid can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select options