4-Aminophenol

4-Aminophenol structural formula

CAS Number123-30-8
Molecular FormulaC6H7NO
Molecular Weight109.128
InChI KeyPLIKAWJENQZMHA-UHFFFAOYSA-N
LogP0.04
Synonyms
  • 4-Aminophenol
  • Phenol, 4-amino-
  • 123-30-8
  • Phenol, 4-amino-
  • 1-Amino-4-hydroxybenzene
  • 4-Amino-1-hydroxybenzene
  • 4-aminofenol
  • 4-Hydroxy-1-aminobenzene
  • 4-Hydroxyaniline
  • 4-Hydroxybenzenamine
  • 4-Hydroxyphenylamine
  • BASF Ursol P Base
  • Benzofur P
  • C.I. Oxidation Base 6
  • Certinal
  • Durafur Brown RB
  • Fouramine P
  • Fourrine 84
  • Fourrine P Base
  • Furro P base
  • Nako Brown R
  • NSC 1545
  • Oxidation Base 6
  • P-AMINOPHENOL
  • Paranol
  • Pelagol Grey P Base
  • Pelagol P Base
  • Phenol, 4-amino
  • Phenol, p-amino-
  • p-Hydroxyaniline
  • p-Hydroxyphenylamine
  • Renal AC
  • Rodinal
  • Tertral P Base
  • Ursol P
  • Ursol P Base
  • Zoba Brown P Base
  • EINECS 204-616-2
  • p-Aminofenol
  • UNII-R7P8FRP05V
  • Activol
  • Aminophenol
  • Energol
  • Paramidophenol
  • 52985-09-8

Applications:

HPLC Method for Analysis of 4-Aminophenol on Primesep 100  Column

February 1, 2023

HPLC Method for Analysis of 4-Aminophenol on Primesep 100 by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Analysis of 4-Aminophenol on Primesep 100  Column
High Performance Liquid Chromatography (HPLC) Method for Analysis of 4-Aminophenol on Primesep 100 by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of 4-Aminophenol on Primesep 100 by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of 4-Aminophenol on Primesep 100 by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analyses of 4-Aminophenol

4-Aminophenol (also known as para-aminophenol or Rodinal) is a popular film developing compound and building block in organic chemistry reactions. Most notably, it is a key compound used in the production of acetaminophen (also known as paracetamol or Tylenol). 4-Aminophenol can be separated, retained, and analyzed on a Primesep 100 mixed-mode stationary phase column using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and an sulfuric acid (H2SO4) or Perchloric acid (HClO4)buffer. This analysis method can be detected in the UV regime at 275 nm.

Condition

ColumnPrimesep 100, 4.6×150 mm, 5 µm, 100A
Mobile PhaseMeCN – 10%
BufferH2SO4 – 0.2% or HClO4 – 0.2%
Flow Rate1.0 ml/min
DetectionUV 200, 210, 275 nm
Peak Retention Time3.7 min, 6.9

Description

Class of CompoundsAlcohols, Phenols, Amines, Amine Salts
Analyzing Compounds4-Aminophenol

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
4-Aminophenol
4-Aminophenol hydrochloride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Separation of Acetaminophen and 4-Aminophenol on Primesep 100  Column

January 31, 2023

HPLC Method for Separation of Acetaminophen and 4-Aminophenol on Primesep 100 by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Separation of Acetaminophen and 4-Aminophenol on Primesep 100 by SIELC Technologies
HPLC Method for Separation of Acetaminophen and 4-Aminophenol on Primesep 100 by SIELC Technologies
HPLC Method for Separation of Acetaminophen and 4-Aminophenol on  <a href='https://sielc.com/product/primesep-100'>Primesep 100</a> by SIELC Technologies
HPLC Method for Separation of Acetaminophen and 4-Aminophenol on Primesep 100 by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Separation of Acetaminophen and 4-Aminophenol

4-Aminophenol (also known as para-aminophenol or Rodinal) is a popular film developing compound and building block in organic chemistry reactions. Most notably, it is a key compound used in the production of acetaminophen (also known as paracetamol or Tylenol). 4-Aminophenol can be separated, retained, and analyzed on a Primesep 100 mixed-mode stationary phase column using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and an sulfuric acid (H2SO4) or perchloric acid (HClO4) buffer. This analysis method can be detected in the UV regime at 220 nm.

Condition

ColumnPrimesep 100, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN – 10%
BufferH2SO4 – 0.2% or HClO4 – 0.2%
Flow Rate1.0 ml/min
DetectionUV 220 nm
Peak Retention Time4.25, 5.51 min

Description

Class of CompoundsAlcohols, Phenols, Amines, Amine Salts, Dgru
Analyzing Compounds4-Aminophenol, Acetaminophen

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

Add to cart
Application Analytes:
4-Aminophenol
Acetaminophen (Paracetamol)
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of 4-Aminophenol MS-compatible Mobile on Primesep 100  Column

December 9, 2022

High Performance Liquid Chromatography (HPLC) Method for Analysis of 4-Aminophenol MS-compatible Mobile Phase on Primesep 100 by SIELC Technologies.

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Analysis of 4-Aminophenol on Primesep 100 Column by SIELC Technologies
HPLC Method for Analysis of 4-Aminophenol on Primesep 100 Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analyses of 4-Aminophenol

4-Aminophenol (also known as para-aminophenol or Rodinal) is a popular film developing compound and building block in organic chemistry reactions. Most notably, it is a key compound used in the production of acetaminophen (also known as paracetamol or Tylenol). 4-Aminophenol can be separated, retained, and analyzed on a Primesep 100 mixed-mode stationary phase column using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and an Ammonium Formate (AmFm) buffer. This analysis method can be detected in the UV regime at 275 nm, and due to the Ammonium Formate buffer, is also compatible with evaporative detectors such as Evaporative Light Scattering Detectors (ELSD), Charged Aerosol Detection (CAD), and Electrospray Ionization (ESI) for Mass Spectrometry (MS).

Condition

ColumnPrimesep 100, 4.6×150 mm, 5 µm, 100A
Mobile PhaseMeCN – 10%
BufferAmmonium Formate pH 3.0 – 20 mM
Flow Rate1.0 ml/min
DetectionUV 275 nm
Peak Retention Time3.7, 5.8 min

Description

Class of CompoundsAlcohols, Phenols, Amines, Amine Salts
Analyzing Compounds4-Aminophenol

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
4-Aminophenol
4-Aminophenol hydrochloride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Acetaminophen and 4-Aminophenol on Primesep C

May 27, 2015

 

Acetaminophen and 4-Aminophenol ar both aminophenols. Acetominophen or paracetamol is a widely used analgesic and antipyretic. 4-Aminophenol is an intermediate in the synthesis of paracetamol and used in photography as a developer. Both compounds were retained and resolved on Primesep C. Primesep C is a mixed-mode HPLC column which uses reversed-phase and unique complex-forming groups to resolve compounds that might otherwise coelute.

 

Condition

Column Primesep C, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN
Buffer TEAPh
Flow Rate 1.0 ml/min
Detection UV, 210 nm

Description

Class of Compounds
 Drug,  Hydrophilic, Ionizable
Analyzing Compounds Acetaminophen,  4-Aminophenol

 

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
4-Aminophenol
Acetaminophen (Paracetamol)

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.