Mandelic Acid

Mandelic Acid structural formula

CAS Number90-64-2
Molecular FormulaC8H8O3
Molecular Weight152.149
InChI KeyIWYDHOAUDWTVEP-UHFFFAOYSA-N
LogP0.62
Synonyms
  • Mandelic acid
  • Hydroxy(phenyl)acetic acid
  • Benzeneacetic acid, alpha-hydroxy-
  • 90-64-2
  • Benzeneacetic acid, alpha-hydroxy-
  • (+/-)-2-Hydroxy-2-phenylethanoic acid
  • (+/-)-Mandelic acid
  • (+/-)-alpha-Hydroxybenzeneacetic acid
  • (+/-)-alpha-Hydroxyphenylacetic acid
  • (RS)-Mandelic acid
  • 2-Hydroxy-2-phenylacetic acid
  • 2-Phenyl-2-hydroxyacetic acid
  • 2-Phenylglycolic acid
  • Acide mandelique
  • acido mandelico
  • Almond acid
  • alpha-Hydroxy-Phenylacetic acid
  • Amygdalic acid
  • D,L-MANDELSAEURE
  • DL-Amygdalic acid
  • DL-Hydroxy(phenyl)acetic acid
  • dl-Mandelic acid
  • Mandelsaure
  • NSC 7925
  • Paramandelic acid
  • Phenylglycolic acid
  • Phenylhydroxyacetic acid
  • Uromaline
  • alpha-Hydroxybenzeneacetic acid
  • alpha-Hydroxybenzeneacetic acid, (.+-.)-
  • alpha-Hydroxyphenylacetic acid
  • alpha-Hydroxy-α-toluic acid
  • EINECS 202-007-6
  • EINECS 210-277-1
  • Glycolic acid, phenyl-
  • p-Mandelic acid
  • Racemic mandelic acid
  • alpha-Toluic acid, alpha-hydroxy-
  • 2-Hydroy-2-phenylacetic acid
  • Kyselina 2-fenyl-2-hydroxyethanova
  • Kyselina mandlova
  • UNII-NH496X0UJX
  • (2S)-2-hydroxy-2-phenylacetic acid
  • (RS)-Mandelate
  • 2-Hydroxy-2-phenylacetate
  • 2-Hydroxy-2-phenylethanoate
  • 2-Hydroxy-2-phenylethanoic acid
  • 2-Phenyl-2-hydroxyacetate
  • 2-Phenylglycolate
  • Amygdalate
  • DL-Amygdalate
  • DL-Hydroxy(phenyl)acetate
  • DL-Hydroxy(phenyl)acetic acid
  • DL-Mandelate
  • Mandelate
  • Paramandelate
  • Phenylglycolate
  • Phenylhydroxyacetate
  • a-Hydroxy-a-toluate
  • a-Hydroxy-a-toluic acid
  • a-Hydroxybenzeneacetate
  • a-Hydroxybenzeneacetic acid
  • a-Hydroxyphenylacetate
  • a-Hydroxyphenylacetic acid
  • alpha-Hydroxy-alpha-toluate
  • alpha-Hydroxy-alpha-toluic acid
  • alpha-Hydroxybenzeneacetate
  • alpha-Hydroxyphenylacetate
  • 15769-78-5
  • 611-72-3
  • 71036-61-8

Applications:

HILIC Separation of Carboxylic Acids

August 22, 2008

Hydrophilic acids are separated on Obelisc N mixed-mode HILIC column. Seven carboxylic acids are separated based on their polarity and pKa values. Changes in ionization states of acids and stationary phase can be used to control elution order of organic and inorganic acids.

Application Column

Obelisc N

SIELC has developed the Obelisc™ columns, which are mixed-mode and utilize Liquid Separation Cell technology (LiSC™). These cost-effective columns are the first of their kind to be commercially available and can replace multiple HPLC columns, including reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion-exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters - buffer concentration, buffer pH, and organic modifier concentration - users can adjust the column properties with pinpoint precision to separate complex mixtures.

Select options
Application Analytes:
Fumaric Acid
Hydroxybenzoic Acid
Malic Acid
Mandelic Acid
Methylmalonic Acid
Organic Acids
Succinic Acid
Tartaric Acid

Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Complex Mixture of Acids, Bases, Amino Acids, and Neutral Compounds

October 14, 2006

Primesep 100 separates a mixture of amino acids (tyrosine, phenylalanine), organic acids (benzoic acid, mandelic acid), amines (benzylamine, pyridine), and neutrals (benzonitrile, toluene) in one HPLC run by combining reversed-phase, cation-exchange, and polar interactions. The method is tunable and peak order can be changed significantly by adjusting acetonitrile and trifluoroacetic acid concentrations. The separation method uses a mobile phase mixture of water, acetonitrile (MeCN, ACN) and trifluoracetic acid (TFA) and compatible with UV, mass spec (LC/MS) and evaporative light scattering (ELSD) detection.

Condition

Column Primesep 100, 4.6×250 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 30/70%
Buffer TFA – 0.2
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements, Amino acid
Analyzing Compounds Tyrosine, phenylalanine, Benzoic acid, mandelic acid, Benzylamine, Pyridine, Benzonitrile, Toluene

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Amino Acids
Benzoic Acid
Benzonitrile
Benzylamine
Mandelic Acid
Organic Acids
Phenylalanine
Pyridine
Toluene
Tyrosine

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.