Nutrasweet

Nutrasweet structural formula

CAS Number22839-47-0
Molecular FormulaC14H18N2O5
Molecular Weight294.308
InChI KeyIAOZJIPTCAWIRG-QWRGUYRKSA-N
LogP0.0904
Synonyms
  • Aspartame
  • Methyl L-alpha-aspartyl-L-phenylalaninate
  • L-Phenylalanine, L-alpha-aspartyl-, methyl ester
  • 22839-47-0
  • L-Phenylalanine, L-α-aspartyl-, 2-methyl ester
  • aspartam
  • aspartamo
  • Aspartylphenylalanine methyl ester
  • Canderel
  • Dipeptide sweetener
  • L-Aspartame
  • L-Aspartyl-L-3-phenylalanine methyl ester
  • L-Aspartyl-L-phenylalanine methyl ester
  • L-Aspartyl-L-phenylalanyl methyl ester
  • L-Phenylalanine, N-L-α-aspartyl-, 1-methyl ester
  • L-α-Aspartyl-L-phenylalanine methyl ester
  • Methyl aspartylphenylalanate
  • NutraSweet
  • Pal Sweet
  • Palsweet Diet
  • PHENYLALANINE (L), N-L-α-ASPARTYL-O-METHYL-
  • Succinamic acid, 3-amino-N-(α-carboxyphenethyl)-, N-methyl ester, stereoisomer
  • α-Aspartame
  • α-L-Aspartyl-L-phenylalanine methyl ester
  • α-Sweet
  • 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester, stereoisomer
  • 3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid
  • Aspartame, L,L-alpha-
  • N-L-alpha-Aspartyl-L-phenylalanine 1-methyl ester
  • EINECS 245-261-3
  • Methyl L-alpha-aspartyl-L-phenylalanate
  • Methyl N-L-alpha-aspartyl-L-phenylalaninate
  • Methyl L-aspartyl-L-phenylalanine
  • 1-Methyl N-L-alpha-aspartyl-L-phenylalanine
  • Tri-sweet
  • Aspartamum
  • UNII-Z0H242BBR1
  • (3S)-3-amino-3-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]carbamoyl}propanoic acid
  • 1-methyl N-L-alpha-aspartyl-L-phenylalanate
  • 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester
  • 3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid
  • Asp-phe-ome
  • E 951
  • L-Aspartyl-L-phenylalanine methyl ester
  • Sweet dipeptide
  • 172964-81-7
  • 53906-69-7
  • 7421-84-3

Applications:

Bufferless Ion Separation (BLIS™) Chromatography of Aspartame: Organic Modifier Effect

January 30, 2005

An organic modifier effect of changing acetonitrile percentage the mobile phase is demonstrated on a Primesep C HPLC column in a bufferless ion (BLIS™) separation. With decreasing percent acetonitrile, the artificial sweetener, Aspartame, first deceases in retention time and then increases. The changing mobile phase composition changes the retention mechanism from hydrophobic and BLIS™interactions, to BLIS™ alone , to BLIS™ and HILIC (hydrophilic liquid chromatography) interactions. Aspartame is composed of the two amino acids, aspartic acid and phenylalanine as the ethyl ester. Mobile phases composed of water and acetonitrile (MeCN, ACN,) and ultraviolet (UV) detection was used.

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Aspartame
Nutrasweet

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.