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Compound: Phenylephrine
HPLC Separation of Polar Drugs with MS-compatible Method |
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Application Notes: Application Analytes: Application Detection: |
Effect of pH on Retention of Basic Compounds on Primesep C Columns |
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Application Notes: Application Analytes: Application Detection: |
HPLC Separation of Acetaminophen, Phenylephrine, and Diphenhydramine |
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Application Notes: Primesep C separates acetaminophen (paracetamol), phenylephrine, and diphenhydramine-- common over-the-counter cold and flu medication ingredients such as Tylenol products—by either an acetonitrile or phosphoric acid gradient. The HPLC separation uses a mobile phase of water, acetonitrile (MeCN, ACN), and phosphoric acid with ultraviolet (UV) detection at 210 nm. Application Analytes: Application Detection: |
HPLC Separation of Phenylephrine with Tannic Acid Formulation |
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Application Notes: Application Analytes: Application Detection: |
HPLC Separation of Caffeine and Phenylephrine |
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HPLC Separation of Neurotransmitters and Related Drugs |
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Application Notes: Epinephrine and norepinephrine (adrenaline and noradrenaline) are hormones and neurotransmitters. Epinephrine is synthesized from norepinephrine in a synthetic pathway shared by all catecholamines, including L-dopa, dopamine, norepinephrine, and epinephrine. Phenylephrine is used as a decongestant, available as an oral medicine or as a nasal spray. Phenylephrine is now the most common over-the-counter (OTC) decongestant. All three compounds are used in various drug compositions. Separation of epinephrine and norepinephrine is a challenging task due to polarity and close properties of two compounds. Epinephrine, norepinephrine and phenylephrine are separated in this method on Obelisc R mixed-mode HPLC columns. Method is very sensitive to variation of pH and pH adjustment can be used to achieve desired selectivity and retention time. Other catecholamines can be analyzed using this HPLC method. Method can be used as stability indicating or impurity profiling approach to analysis of neurotransmitters in drug formulation, blood, serum and urine. Application Analytes: Application Detection: |
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Copyright © SIELC Technologies. 2002-2007
Copyright © SIELC Technologies. 2002-2007