Compound: Ibandronic Acid

HPLC Separation of Alendronic, Ibandronic, Etidronic Acids

Application Notes:

Dronic acids are bisphosphonates that differ in their alkyl chains. Alendronate (Fosamax) marketed alone is used for osteoporosis and other bone diseases. It is also combined with Vitamin C (Fosavance). A short, 50 mm Primesep SB column separates alendronic, ibandronic, and etidronic acids. The HPLC separation uses a mobile phase of water, acetonitrile (MeCN, ACN), trifluoracetic acid (TFA) or ammonium formate and evaporative light scattering detection (ELSD) with a column temperature of 80C.

Application Analytes:

Alendronic Acid
Ibandronic Acid
Etidronic Acid

Application Detection:

ELSD
LC/MS

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