Etodolac

111

CAS Number41340-25-4
Molecular FormulaC17H21NO3
Molecular Weight287.359
InChI KeyNNYBQONXHNTVIJ-UHFFFAOYSA-N
LogP3.49
Synonyms
  • Etodolac
  • (1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
  • Pyrano[3,4-b]indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-
  • 41340-25-4
  • Pyrano[3,4-b]indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-
  • (.+-.)-Etodolac
  • (RS)-Etodolic acid
  • 1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
  • Acide 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetique
  • Etodine
  • Etodolic acid
  • Etogesic
  • Lodin XL
  • Napilac
  • NSC 282126
  • Ramodar
  • Tedolan
  • Ultradol
  • Zedolac
  • Lodine XL
  • Etodolaco
  • Etodolacum
  • UNII-2M36281008
  • (+-)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
  • 1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid
  • 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
  • 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid

Applications:

HPLC Chiral Separation of Etodolac Enantiomers on Cyralis CM Column

July 15, 2026

HPLC Chiral Method for Analysis of Etodolac Enantiomers on Cyralis CM Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Etodolac.

Etodolac is a pyrenecarboxylic acid non-steroidal anti-inflammatory drug (NSAID) with the chemical formula C17H21NO3. It is used primarily to manage mild to moderate pain, fever, and inflammation through reducing the levels of prostaglandins.

This application describes a normal-phase chiral HPLC method for the separation of Etodolac enantiomers using SIELC’s Cyralis CM chiral column. Cyralis CM is a cellulose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications. For best results, the sample should be prepared fresh for analysis.

Etodolac can be retained and analyzed using the Cyralis CM stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of Hexane, IPA, and TFA. Detection is performed using UV.

Condition

ColumnCyralis CM, 4.6 x 100 mm, 5 µm, 100 A, dual ended
Mobile PhaseHexane/IPA/TFA
Flow Rate1.0 mL/min
DetectionUV 230 nm
Resolution4.78

Description

Class of CompoundsDrug
Analyzing CompoundsEtodolac

Application Column

Cyralis CM

Column Diameter: 4.6 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Etodolac
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Etodolac

May 10, 2016

14

Etodolac is a pyrenecarboxylic acid and non-steroidal anti-inflammatory drug (NSAID). It reduces pain, swelling, and joint stiffness by blocking the production of certain natural substances that cause inflammation. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Meclizine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.

 

Condition
Column Primesep 200, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN – 40%
Buffer H3PO4 – 0.1%,
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

Description
Class of Compounds
 Drug,  Acid, Hydrophilic, Ionizable, Supplements
Analyzing Compounds Etodolac

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Etodolac
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.