Hydrochlorothiazide

Hydrochlorothiazide structural formula

CAS Number58-93-5
Molecular FormulaC7H8ClN3O4S2
Molecular Weight297.731
InChI KeyJZUFKLXOESDKRF-UHFFFAOYSA-N
LogP-0.0700
Synonyms
  • Hydrochlorothiazide
  • 6-Chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide
  • 58-93-5
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide
  • 3,4-Dihydrochlorothiazide
  • 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 6-Chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Chloro-7-sulfamoyl-3,4-dihydrobenzo-1,2,4-thiadiazine-1,1-dioxide
  • Acuretic
  • Apo-Hydro
  • Apresazide
  • Aquarius
  • Aquazide
  • Aquazide H
  • Caplaril
  • Carozide
  • Chlorosulthiadil
  • Chlorsulthiadil
  • Clorana
  • Clothia
  • Dichlothiazide
  • Dichlotiazid
  • Dichlotride
  • Dichlozid
  • Diclotride
  • Didralin
  • Dihydrochlorothiazide
  • Dihydrochlorothiazidum
  • Dihydrochlorurit
  • Dihydrochlorurite
  • Disalunil
  • Disothiazide
  • Diuret-P
  • Diurizid
  • Esidrex
  • Esidrix
  • Hidrenox
  • Hidrochlortiazid
  • hidroclorotiazida
  • Hidrosaluretil
  • Hidrotiazida
  • Hydrex-semi
  • Hydro Par
  • Hydro-Aquil
  • Hydrochlorothiazid
  • Hydrochlorthiazide
  • Hydrochlorzide
  • Hydrocot
  • Hydrodiuretic
  • Hydro-Diuril
  • Hydrosaluric
  • Hydro-T
  • Hydrozide
  • Hypothiazid
  • Hypothiazide
  • Idrodiuvis
  • Idrotiazide
  • Lopressor HCT
  • Lotensin HCT
  • Manschitt
  • Maschitt
  • Megadiuril
  • Microzide
  • Natrimax
  • Neoflumen
  • Newtolide
  • NSC 53477
  • Pantemon
  • Servithiazid
  • Tandiur
  • Thiuretic
  • Timolide
  • Unipres
  • Vaseretic
  • Vetidrex
  • Aldactazide 25/25
  • Aldectazide 50/50
  • Aquazide-H
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1, 1-dioxide
  • BRN 0625101
  • Chlorizide
  • 3,4-Dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
  • Diu-melusin
  • EINECS 200-403-3
  • Hydrochlorthiazidum
  • Inderide 80/25
  • Mazide 25 mg
  • Mictrin
  • NCI-C55925
  • Spironazide
  • Neo-Flumen
  • Acesistem
  • Acuilix
  • Aldazida
  • Briazide
  • Catiazida
  • Chlothia
  • Condiuren
  • Dihydran
  • Disothiazid
  • Diu 25 Vigt
  • Diurogen
  • Dixidrasi
  • Esoidrina
  • HCT-Isis
  • Hidro-Niagrin
  • Hyclosid
  • Hydrochlorothiazidum
  • Hydro-Saluric
  • Indroclor
  • Manuril
  • Medozide
  • Mikorten
  • Modurcen
  • Natrinax
  • Neo-Minzil
  • Novodiurex
  • Raunova Plus
  • Saldiuril
  • Selozide
  • Urozide
  • Concor Plus
  • Hydrochlorot
  • Hydrochlorat
  • Idroclorotiazide
  • UNII-0J48LPH2TH
  • 6-chloro-1,1-dioxo-3,4-dihydro-2H-1l6,2,4-benzothiadiazine-7-sulfonamide
  • Aldactazide
  • Aldoril
  • Aquarills
  • Bremil
  • Capozide
  • Chlorosulthiadil
  • Chlorothiazide
  • Chlorsulfonamidodihydrobenzothiadiazine dioxide
  • Chlorzide
  • Cidrex
  • Dichlorosal
  • Dihydrochlorothiazid
  • Dihydrochlorothiazidum
  • Dihydroxychlorothiazidum
  • Direma
  • Diuril
  • Drenol
  • Dyazide
  • Esidrix (TN)
  • Esimil
  • Fluvin
  • HCTZ
  • HCZ
  • Hidril
  • Hidrochlortiazid
  • Hidroronol
  • Hydril
  • Hydro-D
  • Hydrochloro Thiazide
  • Hydrochlorothiazide Intensol
  • Hydrodiuril
  • Hydropres
  • Hydrothide
  • Hyzaar
  • Inderide
  • Ivaugan
  • Jen-Diril
  • Maxzide
  • Moduretic
  • Nefrix
  • Neo-codema
  • Oretic
  • Panurin
  • Prinzide
  • Ro-hydrazide
  • Ser-Ap-Es
  • Thiaretic
  • Thlaretic
  • Urodiazin
  • Ziac
  • Zide
  • 125727-50-6
  • 8049-49-8

Applications:

HPLC Method for Analysis of Hydrochlorothiazide

April 29, 2016

Chr_1047

Hydrochlorothiazide is a thiazide diuretic often considered the prototypical member of the class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of high blood pressure and swelling due to fluid build-up as well as several disorders such as edema, hypertension, diabetes insipidus, and hypoparathyroidism. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Hydrochlorothiazide. The method is UV compatible and can be used as a general approach for analyzing similar compounds.

Condition

Column Primesep 200, 3.2×100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 5-50%
Buffer Gradient H3PO4 – 0.05-0.3%, 5 min, 4 min hold
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

 

Description

Class of Compounds
Drug,  Acid, Hydrophilic, Ionizable,
Analyzing Compounds Hydrochlorothiazide

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Hydrochlorothiazide

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.