Prednisolone 21-hemisuccinate

Prednisolone 21-hemisuccinate structural formula

CAS Number2920-86-7
Molecular FormulaC25H32O8
Molecular Weight460.524
InChI KeyAPGDTXUMTIZLCJ-CGVGKPPMSA-N
LogP2.09
Synonyms
  • Prednisolone 21-hemisuccinate
  • 4-{[(11beta)-11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl]oxy}-4-oxobutanoic acid
  • Butanedioic acid, mono[(11beta)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl] ester
  • 2920-86-7
  • EINECS 220-861-8
  • Prednisolone bisuccinate
  • Prednisolone succinate
  • Prednisolone 21-succinate
  • Prednisolut
  • Prednisolonbisuccinat
  • UNII-G7080T74ON

Applications:

Separation of Prednisolone 21-hemisuccinate on Newcrom R1 HPLC column

February 16, 2018
Separation of Prednisolone 21-hemisuccinate on Newcrom C18 HPLC column

Prednisolone 21-hemisuccinate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Prednisolone 21-hemisuccinate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.