1-Methylhistidine

1-Methylhistidine structural formula

CAS Number 332-80-9
Molecular Formula C7H11N3O2
Molecular Weight 169.185 g/mol
InChI Key BRMWTNUJHUMWMS-LURJTMIESA-N
LogP -1.50
Synonyms
  • 1-Methylhistidine
  • 1-Methyl-L-histidine
  • L-Histidine, 1-methyl-
  • 332-80-9
  • EINECS 206-368-0
  • NSC 524367
  • UNII-583O01BJ32

Applications:

HPLC Separation of 1-Methylhistidine and 3-Methylhistidine on Primesep 200

 

Application Notes: Methylhistidines are polar amino acids with very similar structures. Methylhistidines are methylated derivative of histidine found in actin. N-methylhistidine is released into urine after the breakdown of actin and myosin. Urinary output of N-methylhistidine is a reliable index of the rate of myofibrillar protein breakdown in musculature. The method for separation of 1-methylhistidine and 3-methylhistidine on Primesep 200 column was developed with LC/MS compatible conditions. This method can be used for quantitation of methylhystidines in urine and other biofluids.

Application Columns: Primesep 200
Application compounds: 1-Methylhistidine, 3-Methylhistidine
Detection technique: UV, LC/MS, ELSD/CAD


Application Analytes:

1-Methylhistidine
3-Methylhistidine