1-Methylxanthine

CAS Number 6136-37-4
Molecular Formula C6H6N4O2
Molecular Weight 166.140 g/mol
InChI Key MVOYJPOZRLFTCP-UHFFFAOYSA-N
LogP -0.270
Synonyms
  • 1-Methylxanthine
  • 1-Methyl-3,7-dihydro-1H-purine-2,6-dione
  • 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-
  • 6136-37-4
  • EINECS 228-108-5
  • 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-
  • UNII-7EE8WCA32U
  • 1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
  • 1-methyl-7H-xanthine

Applications:


HPLC Separation of Caffeine, 3- Methylxanthine, 1- Methylxanthine, Xanthine
    Application Notes: Xanthines are polar neutral compounds which are hard to retain and separate by traditional reversed-phase chromatography. However a hydrogen bonding method makes separation possible due to an observable correlation between the number of hydrogens available for interaction and retention time. Molecules with no hydrogens available for interactions retain less, and compound with multiple hydrogen donors retain the most. Retention time can be controlled by changing ratio of ACN:MeOH. Other protic and aprotic solvents can be used to control retention time and selectivity of separation. Application Columns: SHARC 1, 3.2x100 mm, 5 um, 100A, To learn more about SHARC 1 columns click here. To order this column click here. To see more chromatographic separations check our web site. Application Compounds:  Caffeine, 3-methylxanthine, 1-methylxanthine, and xanthine

Application Analytes:

1-Methylxanthine
3-Methylxanthine
Caffeine
Xanthine