2-Amino-5-methyl-thiazole

CAS Number 7305-71-7
Molecular Formula C4H6N2S
Molecular Weight 114.170 g/mol
InChI Key GUABFMPMKJGSBQ-UHFFFAOYSA-N
LogP 0.426
Synonyms
  • 2-Amino-5-methyl-thiazole
  • 5-Methyl-1,3-thiazol-2-amine
  • 2-Thiazolamine, 5-methyl-
  • 7305-71-7
  • UNII-7RAB78AF2P
  • NSC-523150
  • 2-Thiazolamine, 5-methyl-
  • 5-Methyl-2-thiazolamine
  • 5-Methyl-2-aminothiazole
  • 5-Methyl-1,3-thiazol-2-amine
  • (5-Methylthiazol-2-yl)amine
  • Meloxicam related compound B

Applications:


Separation of 2-Amino-5-methyl-thiazole on Newcrom R1 HPLC column

2-Amino-5-methyl-thiazole can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of 2-Amino-5-methyl-thiazole on Newcrom R1 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.



Application Analytes:

2-Amino-5-methyl-thiazole

Separation of Model Compounds in Reversed-Phase and Mixed-Mode
   

Condition

Column Primesep 100, 3,2x50 mm, 2,7 µm, 100A
Mobile Phase Gradient  MeCN - 10-60%, 5 min
Buffer Gradient AmFm pH 3.5- 30 - 70 mM, 5 min
Flow Rate 1.2 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug,  Basic, Hydrophilic, Hydrophobic, Ionizable.
Analyzing Compounds Adenosine, 3,4-Difluroaniline, 4-Amino-2-chloropyridine, 5-Aminoindole, 4-Amino-3-chloropyridine, 2-Amino 5-methylthiadiazole, 4-Ethylaniline
 

Application Analytes:

2-Amino-5-Methylthiadiazole
2-Amino-5-methyl-thiazole
3,4-Difluoroaniline
4-Amino-2-Chloropyridine
4-Amino-3-Chloropyridine
4-Ethylaniline
5-Aminoindole
Adenosine