2-Hydroxyethyl salicylate

2-Hydroxyethyl salicylate structural formula


CAS Number 87-28-5
Molecular Formula C9H10O4
Molecular Weight 182.176 g/mol
LogP 1.39
  • 2-Hydroxyethyl salicylate
  • 2-Hydroxyethyl 2-hydroxybenzoate
  • Benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester
  • 87-28-5
  • EINECS 201-737-2
  • Espirosal
  • Ethylene glycol, monosalicylate
  • 1,2-Ethylene glycol monosalicylate
  • Ethylene glycol, salicylate
  • Monoglycol salicylate
  • NSC 72097
  • Rheumacyl
  • Sarocol
  • Spirosal
  • Aethylenglykolsalicylat
  • Ethylenglycol-monosalicylsaeureester
  • Glykolsalicylat
  • Traumasenex
  • Phlogont
  • Kytta-gel
  • 2-hydroxybenzoic acid 2-hydroxyethyl ester
  • 2-hydroxyethyl 2-oxidanylbenzoate
  • Ethylene glycol salicylate
  • ethylene glycol monosalicylate


Separation of 2-Hydroxyethyl salicylate on Newcrom R1 HPLC column
2-Hydroxyethyl salicylate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Separation of 2-Hydroxyethyl salicylate on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.

Application Analytes:

2-Hydroxyethyl salicylate

HPLC Separation of Mixture of 2-Hydroxyethyl Salicylate and Salicylic Acid on Primesep B Column
HPLC Separation of Mixture of 2-Hydroxyethyl Salicylate and Salicylic Acid_1182 2-Hydroxyethyl salicylate is a drug used as analgesic agents for the treatment of mild to moderate pain.  


Column Primesep B, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 25/75%
Buffer H2SO4 - 0.5 %
Flow Rate 1.0 ml/min
Detection UV, 238 nm


Class of Compounds Acid, Hydrophilic, Ionizable, Carboxylic acid, Drug, Carbocyclic, Benzoate, Hydroxy Acid, Hydroxybenzoate, Phenol
Analyzing Compounds 2-Hydroxyethyl Salicylate, Salicylic Acid

Application Analytes:

2-Hydroxyethyl salicylate
Salicylic acid

Follow by Email