2-Hydroxyisocaproic Acid (HICA)

CAS Number 498-36-2
Molecular Formula C6H12O3
Molecular Weight 132.16 g/mol
InChI Key LVRFTAZAXQPQHI-UHFFFAOYSA-N
LogP 0.9
Synonyms
  • 2-Hydroxy-4-methylpentanoic acid
  • 498-36-2
  • 2-Hydroxy-4-methylvaleric acid
  • DL-leucic acid
  • 2-Hydroxyisocaproic acid
  • Leucic acid
  • alpha-Hydroxyisocaproic acid
  • leucinic acid
  • 2-HYDROXY-4-METHYL-PENTANOIC ACID
  • Pentanoic acid, 2-hydroxy-4-methyl-
  • DL-2-Hydroxyisocaproic acid
  • d-alpha-hydroxyisocaproic acid
  • DL-alpha-Hydroxyisocaproic acid
  • 10303-64-7
  • DL-2-Hydroxy-4-methylvaleric acid
  • 2-hydroxyisohexanoic acid
  • CHEBI:59783
  • LVRFTAZAXQPQHI-UHFFFAOYSA-N
  • MFCD00004246
  • 2-Hydroxyisocaproate
  • alpha-Hydroxyisocaproate
  • 2-Hydroxy-4-methylpentanoate
  • (+-)-Leucinic acid
  • Leucate
  • DL-Leucate
  • (2S)-2-Hydroxy-4-methyl-pentanoic acid
  • a-Hydroxyisocaproate
  • EINECS 207-860-8
  • EINECS 233-677-8
  • HICA
  • 2-Hydroxyisohexanoate
  • a-Hydroxy-iso-caproate
  • DL-a-Hydroxyisocaproate
  • PubChem22723
  • a-Hydroxyisocaproic acid
  • DL-2-Hydroxyisocaproate
  • AC1L3OTG
  • alpha-Hydroxy-iso-caproate
  • a-Hydroxy-iso-caproic acid
  • bmse000338
  • DL-alpha-Hydroxyisocaproate
  • AC1Q1P3I
  • DL-a-Hydroxyisocaproic acid
  • 2-hydroxy-4-methyl-Valerate
  • SCHEMBL185354
  • alpha-Hydroxy-iso-caproic acid
  • 2-Hydroxyisocaproic acid, 99%
  • CHEMBL3247392
  • CTK8D8669
  • DL-2-Hydroxy-4-methylpentanoate
  • KS-00000YQG
  • LVRFTAZAXQPQHI-UHFFFAOYSA-
  • 2-hydroxy-4-methyl-Valeric acid
  • 4-methyl-2-oxidanyl-pentanoic acid
  • 2-Hydroxy-4-methylpentanoic acid
  • #BBL003540
  • DL-2-Hydroxy-4-methylpentanoic acid
  • LMFA01050381

Applications:


HPLC Separation of β‑Hydroxy-β-methylbutyric Acid, 2-Hydroxyisocaproic Acid and Leucine on Primesep 100 Column
Both β-hydroxy-β-methylbutyric acid (HMB) and 2-hydroxyisocaproic acid (HICA) are metabolites of the essential dietary branched chain amino acid leucine.
 

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN - 5%, 3 min hold, Gradient MeCN 5-30% 12 min
Buffer H2SO4 - 0.05 % 3 min hold, GradientH2SO4 0.05-3% 12 min
Flow Rate 1.0 ml/min
Detection UV, 210 nm
 

Description

Class of Compounds Acid, Hydrophilic,  Ionizable, Normal human metabolite, Dietary supplement, Essential amino acid, Branched-chain amino acid (BCAA)
Analyzing Compounds β‑Hydroxy-β-methylbutyric (HMB), 2-Hydroxyisocaproic Acid (HICA), Leucine
 

Application Analytes:

2-Hydroxyisocaproic Acid (HICA)
D-Leucine
Leucine
β‑Hydroxy-β-methylbutyric Acid (HMB)

HPLC Separation of β‑Hydroxy-β-methylbutyric Acid and 2-Hydroxyisocaproic Acid on Primesep 100 Colimn
HPLC Separation of β‑Hydroxy-β-methylbutyric Acid and 2-Hydroxyisocaproic Acid_1182
Both β-hydroxy-β-methylbutyric acid (HMB) and 2-hydroxyisocaproic acid (HICA) are metabolites of the essential dietary branched chain amino acid leucine.
 

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN - 5%
Buffer H2SO4 - 0.05 %
Flow Rate 1.0 ml/min
Detection UV, 210 nm
 

Description

Class of Compounds Acid, Hydrophilic,  Ionizable, Normal human metabolite, Dietary supplement, Essential amino acid, Branched-chain amino acid (BCAA)
Analyzing Compounds β‑Hydroxy-β-methylbutyric (HMB), 2-Hydroxyisocaproic Acid (HICA)
 


Application Analytes:

2-Hydroxyisocaproic Acid (HICA)
β‑Hydroxy-β-methylbutyric Acid (HMB)