3-Methylhistidine

CAS Number 368-16-1
Molecular Formula C7H11N3O2
Molecular Weight 169.184 g/mol
InChI Key JDHILDINMRGULE-LURJTMIESA-N
LogP -3.3
Synonyms
  • 1-Methylhistidine
  • 3-Methyl-L-histidine
  • 3-Methylhistidine
  • L-Histidine, 3-methyl-
  • 3,methylhistidine
  • Tau-methylhistidine
  • (S)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid
  • L-3-Methylhistidine
  • H-His(3-Me)-OH
  • N(pi)-Methyl-L-histidine
  • N-pros-Methyl-L-histidine
  • N(pai)-Methyl-L-histidine
  • N(pros)-methyl-L-histidine
  • (2S)-2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid
  • 3-N-Methyl-L-histidine
  • pi-Methyl-L-histidine
  • EINECS 206-704-6
  • 1-Methylhistidine
  • #Tau-Methyl-L-histidine
  • N3-Methyl-L-histidine

Applications:


HPLC Separation of 1-Methylhistidine and 3-Methylhistidine on Primesep 200

 

Application Notes: Methylhistidines are polar amino acids with very similar structures. Methylhistidines are methylated derivative of histidine found in actin. N-methylhistidine is released into urine after the breakdown of actin and myosin. Urinary output of N-methylhistidine is a reliable index of the rate of myofibrillar protein breakdown in musculature. The method for separation of 1-methylhistidine and 3-methylhistidine on Primesep 200 column was developed with LC/MS compatible conditions. This method can be used for quantitation of methylhystidines in urine and other biofluids.

Application Columns: Primesep 200
Application compounds: 1-Methylhistidine, 3-Methylhistidine
Detection technique: UV, LC/MS, ELSD/CAD



Application Analytes:

1-Methylhistidine
3-Methylhistidine