4-Methoxyphenol

CAS Number 150-76-5
Molecular Formula C7H8O2
Molecular Weight 124.139 g/mol
InChI Key NWVVVBRKAWDGAB-UHFFFAOYSA-N
LogP 1.58
Synonyms
  • 4-Methoxyphenol
  • Phenol, 4-methoxy-
  • 150-76-5
  • Hydroquinone monomethyl ether
  • p-Methoxyphenol
  • Phenol, 4-methoxy-
  • 1-Hydroxy-4-methoxybenzene
  • 4-Hydroxyanisole
  • BENZENE, 1-METHOXY-4-HYDROXY-
  • HYDROCHINON-MONOMETHYLAETHER
  • Hydroquinone methyl ether
  • Leucobasal
  • Leucodine B
  • Mechinolum
  • Mequinol
  • Novo-Dermoquinona
  • NSC 4960
  • p-Guaiacol
  • Phenol, p-methoxy-
  • p-Hydroxyanisol
  • p-Hydroxyanisole
  • p-Hydroxymethoxybenzene
  • EINECS 205-769-8
  • Mono methyl ether hydroquinone
  • Monomethyl ether hydroquinone
  • Mechinolo
  • Mequinolum
  • UNII-6HT8U7K3AM

Applications:


Separation of 4-Methoxyphenol on Newcrom R1 HPLC column
Separation of 4-Methoxyphenol on Newcrom C18 HPLC column
4-Methoxyphenol can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.


Application Analytes:

4-Methoxyphenol

HPLC Separation of Acrylic Acid and 4- Methoxyphenol on Primesep B Column
Acrylic acid in combination with other monomers produces copolymers which are used in manufacturing of various products such as paints, adhesives and plastics. Esters and salts of acrylic acid are known as acrylates. 4-methoxyphenol, also known as mequinol, is an active ingredient in topical drugs and is also used for inhibition of radical polymerization of monomers like acrylates. The two compounds can be separated on a mixed-mode Primesep B column with isocratic method in mobile phase of 20/80 Acetonitrile (ACN) and water with 0.02% phosphoric acid buffer. UV Detection 200nm.  
 

Condition

Column Primesep B, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 20/80%
Buffer H3PO4 - 0.02 %
Flow Rate 1.0 ml/min
Detection UV, 200 nm
 

Description

Class of Compounds Acid, Hydrophilic, Ionizable, Antioxidant, Inhibitor, Phenol, Carboxylic acid
Analyzing Compounds  Acrylic Acid,  4- Methoxyphenol, Mequinol
 

Application Analytes:

4-Methoxyphenol
Acrylic acid