5-Hydroxymethyl-2-furaldehyde (5-HMF)

CAS Number67-47-0
Molecular FormulaC6H6O3
Molecular Weight126.11
InChI KeyNOEGNKMFWQHSLB-UHFFFAOYSA-N
LogP-0.6
Synonyms
  • 5-HYDROXYMETHYLFURFURAL
  • 67-47-0
  • 5-(hydroxymethyl)furan-2-carbaldehyde
  • 5-Hydroxymethyl-2-furaldehyde
  • 5-(Hydroxymethyl)furfural
  • 5-(Hydroxymethyl)-2-furaldehyde
  • Hydroxymethylfurfural
  • 5-(Hydroxymethyl)-2-furfural
  • 5-Oxymethylfurfurole
  • 5-Hydroxymethylfuraldehyde
  • Hydroxymethylfurfurole
  • 5-Hydroxymethylfuran-2-aldehyde
  • Hydroxymethylfurfuraldehyde
  • Hydroxymethylfurfuralaldehyde
  • 2-Hydroxymethyl-5-furfural
  • 2-Furancarboxaldehyde, 5-(hydroxymethyl)-
  • 5-Hydroxymethyl-2-formylfuran
  • 5-(Hydroxymethyl)-2-furancarbonal
  • 5-(Hydroxymethyl)-2-furfuraldehyde
  • 5-Hydroxymethyl-2-furfural
  • 5-Hydroxymethylfurfuraldehyde
  • 5-hydroxymethyl furfural
  • 5-(Hyddroxymethyl)furfurole
  • 5-(Hydroxymethyl)-2-furancarboxaldehyde
  • 5-Hydroxymethyl-2-furancarboxaldehyde
  • 5-HYDROXYMETHYL-FURFURAL
  • HMF
  • 2-Furaldehyde, 5-(hydroxymethyl)-
  • NSC-40738
  • CHEBI:412516
  • 5-(Hydroxymethyl)furan-2-aldehyde
  • 5-Hydroxymethyl-2-furancarbaldehyde
  • Aes-103
  • 5-HMF

Applications:

HPLC Method for Substituted Furans Separation on Newcrom R1 column

February 10, 2021

HPLC Method for 5-Hydroxymethyl-2-furaldehyde (5-HMF), Furfuryl alcohol, Furfural, 2-Furancarboxylic acid, 3,4-Bis(hydroxymethyl)furan, 5-Hydroxymethyl-2-furancarboxylic acid on Newcrom R1 by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of 5-Hydroxymethyl-2-furaldehyde (5-HMF), Furfuryl alcohol, Furfural, 2-Furancarboxylic acid, 3,4-Bis(hydroxymethyl)furan, 5-Hydroxymethyl-2-furancarboxylic acid.

Furan is a chemical contaminant that forms in some foods during traditional heat treatment techniques, such as cooking, jarring, and canning. 

5-Hydroxymethyl-2-furaldehyde (5-HMF), also known as Hydroxymethylfurfural, is an organic compound with the chemical formula C6H6O3. It can form in sugar-containing food when heated. Due to being considered a potential carcinogen, much research has gone into it’s formation. 

Furfuryl alcohol is a trapping agent with the chemical formula C5H6O2. It is used to synthesize ethyl levulinate, prepare collodial microporous carbon spheres, and as a starting material to prepare cyclopentanone.

Furfural is an organic compound with the chemical formula C5H4O2. IT is found primarily in cooked or heated coffee and whole grain bread. It is used as a renewable chemical feedstock, which can be converted into a variety of useful chemicals.

2-Furancarboxylic acid is an organic compound with the chemical formula C5H4O3. It is used primarily in the production of furoate esters, some of which are drugs and pesticides.  As a flavoring, it is used for it’s sweet, oily, and earthly flavor.

5-Hydroxymethyl-2-furaldehyde (5-HMF), Furfuryl alcohol, Furfural, 2-Furancarboxylic acid, 3,4-Bis(hydroxymethyl)furan, 5-Hydroxymethyl-2-furancarboxylic acid can be retained and separated in HPLC using Newcrom R1 reverse-phase column.  The analytical method’s mobile phase consists of a gradient of acetonitrile (ACN) in water with phosphoric acid (H3PO4) buffer and using UV detection at 210 and 275 nm.

Condition

Column Newcrom R1, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 5/95%
Buffer H3PO4 – 0.1%
Flow Rate 1.0 ml/min
Detection 210, 275 nm

Description

Class of Compounds Hydrophilic, Acid, Aldehyde
Analyzing Compounds 5-Hydroxymethyl-2-furaldehyde (5-HMF), Furfuryl alcohol, Furfural, 2-Furancarboxylic acid, 3,4-Bis(hydroxymethyl)furan, 5-Hydroxymethyl-2-furancarboxylic acid

Application Column

Newcrom R1

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
2-Furancarboxylic acid
3,4-Bis(hydroxymethyl)furan
5-Hydroxymethyl-2-furaldehyde (5-HMF)
5-Hydroxymethyl-2-furancarboxylic acid
Furfural
Furfuryl alcohol

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Determination of 5-Hydroxymethyl-2-furaldehyde (5-HMF) on Newcrom R1 Column by SIELC Technologies

January 29, 2021

HPLC Method for 5-Hydroxymethyl-2-furaldehyde (5-HMF) on Newcrom R1 by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of 5-Hydroxymethyl-2-furaldehyde (5-HMF).

5-Hydroxymethyl-2-furaldehyde (HMF), also known as 5-(Hydroxymethyl)furfural, is an organic compound derived from sugars and is of interest due to its potential as a platform chemical for biofuels and biochemicals.

HMF plays a notable role in the flavor and aroma development of whisky. Understanding its formation, impact, and concentration can provide insights into the aging process and overall quality of the whisky, contributing to the appreciation and enjoyment of this complex beverage.

Furan is a chemical contaminant that forms in some foods during traditional heat treatment techniques, such as cooking, jarring, and canning.

5-Hydroxymethyl-2-furaldehyde (5-HMF) can be retained and separated in HPLC using Newcrom R1 reverse-phase column. The analytical method’s mobile phase consists of a gradient of acetonitrile (ACN) in water with phosphoric acid (H3PO4) buffer and using UV detection at 210 and 275 nm.

ColumnNewcrom R1, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 5/95%
BufferH3PO4 – 0.1%
Flow Rate1.0 ml/min
Detection284 nm
Class of CompoundsHydrophilic
Analyzing Compounds5-Hydroxymethyl-2-furaldehyde (5-HMF)

Application Column

Newcrom R1

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
5-Hydroxymethyl-2-furaldehyde (5-HMF)

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.