Xanthohumol

CAS Number6754-58-1
Molecular FormulaC21H22O5
Molecular Weight354.4
InChI KeyORXQGKIUCDPEAJ-YRNVUSSQSA-N
LogP5.1
Synonyms
  • Xanthohumol
  • 6754-58-1
  • 1-(2,4-Dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
  • 569-83-5
  • UNII-T4467YT1NT
  • T4467YT1NT
  • CHEBI:66331
  • 2',4,4'-trihydroxy-6'-methoxy-3'-prenylchalcone

Applications:

HPLC Determination of Xanthohumol on Newcrom AH Column

April 27, 2020


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Xanthohumol (XN) is a flavonoid compound found in beer that contributes to its flavor and bitterness. There have also been interest in flavonoids and their possible medical applications. Studies have shown that it has anticancer activity and the ability to lower cholesterol and blood sugar. XN can be retained in HPLC on a Newcrom AH mixed-mode column with a mobile phase of acetonitrile (ACN) and water with sulfuric acid (H2SO4) as buffer and UV detected at 370nm.

Condition

Column Newcrom AH, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeOH/H2O – 70/30%
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV 370 nm

 

Description

Class of Compounds Hydrophobic, Acid, Chalconoid
Analyzing Compounds Xanthohumol

Application Column

Newcrom A

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Newcrom AH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Xanthohumol
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