HPLC Separation of Alkyl Sulfonic Acids

Alkyl sulphonic acids are used as surfactant additives in many products. Homologs of linear alkyl sulfonates are separated on a Primesep 500 mixed-mode cation exchange column in reversed-phase anion-exclusion mode. This generic method can be used for determination of alkyl sulfonates in detergents, soaps, etc.


Column Primesep 500,  4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer AmAc
Flow Rate 1.0 ml/min
Detection ELSD


Class of Compounds Acid,  Hydrophilic, Ionizable
Analyzing Compounds Sodium, Hexanesulphonic Acid, Heptanesulphonic Acid, Octanesulphonic Acid

Application Analytes:

Heptanesulfonic Acid
Hexanesulfonic Acid
Octanesulfonic Acid