HPLC Separation of Aromatic Boronic Acids


Boronic acid is alkyl, or aryl substituted, boric acid. Boronic acid can form complexes with sugars, amines, and amino acids. Four aromatic boronic acids were separated on a Primesep P mixed-mode reversed-phase cation-exchange column. Primesep P column also has an aromatic fragment which provides pi-pi interaction. Compounds can be monitored by UV, ELSD, CAD and LC/MS. Various mobile phases can be employed for HPLC analysis of boronic acids.

Application Analytes:

4-(1-naphthyl)phenylboronic acid
4-Chlorophenylboronic acid
Biphenyl-4-boronic acid
Naphthalene-1-boronic acid