HPLC Separation of Cyclodextrin Sulfobutyl Ether and Hydrophobic Compound

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Cyclodextrin sulfobutyl ether is sulfonated derivative of cyclodextrin. The degree of sulfobutylation varies, and the compound is a mixture of several components. All compounds are very polar and acidic in nature, and are not retained by traditional reversed-phase chromatography. Separation was achieved on an Obelisc N column in anion-exchange mode. Hydrophobic naphthalene was used a a reference standard. Cyclodextrin was monitored by ELSD.



Application Analytes:

Betadex Sulfobutyl Ether Sodium