HPLC Separation of Drugs in Tylenol Cold and Cough Remedies



Components of Tylenol Cold and Cough Remedy are separated on Obelisc R mixed-mode column. Method can be used to determine compounds in various cough and cold compositions. Neutral (acetaminophen), basic (chlorpheniramine, dextromethorphan and pseudoephedrine) and acidic (maleic acid/Maleate) components are analyzed with perfect peak shape and retention control. Method can be used in production, QC/QA and biological studies for quantitation of various components in pharmaceutical formulations (Advil, Tylenol, Dimetapp, Robitussin, NyQuil, etc)

Application Analytes:

Acetaminophen (Paracetamol)
Chlorpheniramine
Dextromethorphan
Maleate
Pseudoephedrine (PSE)