HPLC Separation of Salicylic acid

      Salicylic acid is a pain-reliever and anti-inflammatory commonly found in rubefacient products for topical pain relief as well as cosmetic skin-care products used to treat a variety of skin conditions. Legacy L1 was used to retain salicylic acid by reverse phase mechanism.Legacy L1 uses embedded C18 groups on porous silica and is useful for many USP HPLC applications. comparisons to Phenomenex columns are available by request.


Column Legacy L1, 4.6x250 mm, 5 µm, 100A
Mobile Phase MeOH - 45%
Buffer Acetic acid - 0.55%
Flow Rate 1.0 ml/min
Detection UV, 280 nm


Class of Compounds  Acid,  Hydrophilic, Ionizable
Analyzing Compounds Salicylic acid

Application Analytes:

Salicylic acid
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