HPLC Separation of Sodium, Dioctyl Sulfosuccinic Acid, and Sulfosuccinic Acid

Application Notes: Dioctyl sodium sulfosuccinate is a common component of consumer products and medications. It is also used as emulsifier, wetting, and dispersing agent.  It is a highly acidic, and hydrophobic compound. It serves as a starting material for dioctyl sodium sulfonate. Both compounds were retained and separated on Primesep B4 mixed-mode reversed-phase anion-exchange column. The primesep B4 column has C4 carbon chain and it is much less hydrophobic than Primesep D or Primesep B2 column. The low hydrophobicity of the stationary phase is strong enough to provide reversed-phase retention for dioctyl sulfosuccinic acid. This method can be used for quantification of these two compounds in reaction mixtures and formulation. The method is LC/MS and ELSD/CAD compatible.   Application Columns: Primesep B4   Application compounds: Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid Detection technique: LC/MS, ELSD/CAD


Column Primesep B4, 3.2x50 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer AmFm, pH 3.0
Flow Rate 1.0 ml/min
Detection ELSD


Class of Compounds Acid, Hydrophilic, Ionizable
Analyzing Compounds Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid

Application Analytes:

Sulfosuccinic acid
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