Separation of Sodium, Tetramethylammonium and Tetrabutylammonium on Primesep 200 Column

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Hydrophilic and hydrophobic quaternary amines, along with sodium ion, were separated by mixed-mode chromatography on a Primesep 200 column. Mechanism of retention for sodium and tetramethylammonium ions is cation exchange, while the tetrabutylammonium ion is retained by combination of reversed-phase and cation-exchange mechanisms. All three compounds are not UV-active and monitoring is done by ELSD/CAD.



Application Analytes:

Sodium
Tetrabutylammonium
Tetramethylammonium