4-Amino-3-Chloropyridine

4-Amino-3-Chloropyridine

CAS Number 19798-77-7
Molecular Formula C5H5ClN2
Molecular Weight 128.560 g/mol
InChI Key KJBKPRMEMJKXDV-UHFFFAOYSA-N
LogP 0.909
Synonyms
  • 4-Amino-3-chloropyridine
  • 3-Chloropyridin-4-amine
  • 4-Pyridinamine, 3-chloro-
  • 19798-77-7

Applications:


Separation of Model Compounds in Reversed-Phase and Mixed-Mode
  Many compounds are difficult, if not impossible, to separate on reverse-phase columns in HPLC. Other compounds cannot be separated on ion-exchange columns. That’s where the mixed-mode columns come in. By using a stationary phase with both hydrophobic and ion-exchange properties, allows the chromatographer to have additional controls over separation conditions. Here, we demonstrate the separation of compounds that can’t be achieved on a C18 column. By using both an organic gradient and buffer gradient of ammonium formate (AmFm), we can separate structurally similar compounds that can’t be separated on a reverse-phase column alone.  

Condition

Column Primesep 100, 3,2x50 mm, 2,7 µm, 100A
Mobile Phase Gradient  MeCN - 10-60%, 5 min
Buffer Gradient AmFm pH 3.5- 30 - 70 mM, 5 min
Flow Rate 1.2 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug,  Basic, Hydrophilic, Hydrophobic, Ionizable.
Analyzing Compounds Adenosine, 3,4-Difluroaniline, 4-Amino-2-chloropyridine, 5-Aminoindole, 4-Amino-3-chloropyridine, 2-Amino 5-methylthiadiazole, 4-Ethylaniline
 

Application Analytes:

2-Amino-5-Methylthiadiazole
2-Amino-5-methyl-thiazole
3,4-Difluoroaniline
4-Amino-2-Chloropyridine
4-Amino-3-Chloropyridine
4-Ethylaniline
5-Aminoindole
Adenosine

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