Acetylsalicylic Acid

CAS Number 50-78-2
Molecular Formula C9H8O4
Molecular Weight 180.159 g/mol
InChI Key BSYNRYMUTXBXSQ-UHFFFAOYSA-N
LogP 1.2
Synonyms
  • aspirin
  • ACETYLSALICYLIC ACID
  • 2-Acetoxybenzoic acid
  • 50-78-2
  • 2-(Acetyloxy)benzoic acid
  • Acetylsalicylate
  • O-Acetylsalicylic acid
  • o-Acetoxybenzoic acid
  • Acetosal
  • Acylpyrin
  • Polopiryna
  • Ecotrin
  • Salicylic acid acetate
  • Acenterine
  • Acetophen
  • Colfarit
  • Easprin
  • o-Carboxyphenyl acetate
  • Enterosarein
  • Aceticyl
  • Acetonyl
  • Acetosalin
  • Acetylin
  • Aspergum
  • Aspirdrops
  • Benaspir
  • Micristin
  • Pharmacin
  • Premaspin
  • Salcetogen
  • Temperal
  • Ecolen
  • Empirin
  • Endydol
  • Rhodine
  • Saletin
  • Rheumintabletten
  • Solprin acid
  • Acidum acetylsalicylicum
  • Acetisal

Applications:


HPLC Separation of Components of Excedrin



Excedrin is over-the-counter pain reliever containing acetaminophen, caffeine and aspirin as active ingredients of this drug composition. Acetaminophen (paracetamol) is used as analgesic and pain reliever. It is a neutral compound with low hydrophobicity. Aspirin or acetylsalicylic acid is used as analgesic and anti-inflammatory component of many OTC compositions. It is weakly acidic and slightly hydrophobic compound. Caffeine is xanthine alkaloid which is psychoactive stimulant drug. All four compounds are separated on mixed-mode Primesep 100 HPLC column with acetonitrile/water/TFA mobile phase. In this HPLC application compounds are retained by reversed phase mechanism. This HPLC method is short and robust.



Application Analytes:

Acetylsalicylic Acid
Aspirin
Benzoic Acid
Caffeine