Alginic Acid

CAS Number	9005-34-9
Molecular Formula	(C6H11NO6)n
Molecular Weight	398.317 g/mol
InChI Key	GKFPPCXIBHQRQT-UHFFFAOYSA-N
LogP	-3.7
Synonyms	Kaltostat Sodium calcium alginate calginat Kalrostat Vocoloid Xantalgin copper alginate C14H22O13 Alloid G Kalrostat 2 poly(mannuronic acid) alginic acid, copper salt Alginic acid, calcium salt polymannuronic-guluronic acid Landalgine Nouralgine Pectalgine Amnucol Calginate Callatex Combinace Digamon Duckalgin Halltex Kelcosol Kelsize Keltone Lamitex Manucol Manutex Mosanon Protanal Protatek Protomon Stipine Superloid Tragaya Kelgin Kelgum Kelset Keltex Sazzio Minus Tagat Verdyol Super alginate, sodium Cecalgine TBV Dariloid QH Manutex F Protanal LF

Applications:

Separation of Alginic Acid and Related Products

Alginate is used in various pharmaceutical preparations. Chemically, it is a linear copolymer with homopolymeric blocks of (1-4)-linked ?-D-mannuronate (M) and its C-5 epimer ?-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. Alginic acid can be separated from benzoate, citric acid and saccharin by mixed-mode chromatography on Primesep C HPLC column. This method can be used to quantitate alginic acid, citric acid or saccharin in complex mixtures. Various detection technique can be used (UV, ELSD, LC/MS), based on mobile phase selection.

Alginic Acid
Benzoic Acid
Citric Acid
Saccharin

HPLC Analysis of Alginic Acid in Heartburn Tablets

Alginic acid is a linear copolymer with homopolymeric blocks of (1-4)-linked ?-D-mannuronate (M) and its C-5 epimer ?-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. The monomers can appear in homopolymeric blocks of consecutive G-residues (G-blocks), consecutive M-residues (M-blocks), alternating M and G-residues (MG-blocks), or randomly organized blocks. Molecular weight varies from 10,000 to 600,000. Analysis is a challenging task due to a wide distribution of molecular weights. Alginic acid analyzed in ion-exclusion and size exclusion mode on Primesep C mixed-mode cation exchange column. Alginic acid elutes before void as a single peak with good symmetry. Method can be used for quantitation of alginic acid in various formulation. Low UV or ELSD can be employed.

Alginic Acid