Alginic Acid

CAS Number 9005-34-9
Molecular Formula (C6H11NO6)n
Molecular Weight 398.317 g/mol
InChI Key GKFPPCXIBHQRQT-UHFFFAOYSA-N
LogP -3.7
Synonyms
  • Kaltostat
  • Sodium calcium alginate
  • calginat
  • Kalrostat
  • Vocoloid
  • Xantalgin
  • copper alginate
  • C14H22O13
  • Alloid G
  • Kalrostat 2
  • poly(mannuronic acid)
  • alginic acid, copper salt
  • Alginic acid, calcium salt
  • polymannuronic-guluronic acid
  • Landalgine
  • Nouralgine
  • Pectalgine
  • Amnucol
  • Calginate
  • Callatex
  • Combinace
  • Digamon
  • Duckalgin
  • Halltex
  • Kelcosol
  • Kelsize
  • Keltone
  • Lamitex
  • Manucol
  • Manutex
  • Mosanon
  • Protanal
  • Protatek
  • Protomon
  • Stipine
  • Superloid
  • Tragaya
  • Kelgin
  • Kelgum
  • Kelset
  • Keltex
  • Sazzio
  • Minus
  • Tagat
  • Verdyol Super
  • alginate, sodium
  • Cecalgine TBV
  • Dariloid QH
  • Manutex F
  • Protanal LF

Applications:

Separation of Alginic Acid and Related Products
Alginate is used in various pharmaceutical preparations. Chemically, it is a linear copolymer with homopolymeric blocks of (1-4)-linked ?-D-mannuronate (M) and its C-5 epimer ?-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. Alginic acid can be separated from benzoate, citric acid and saccharin by mixed-mode chromatography on Primesep C HPLC column. This method can be used to quantitate alginic acid, citric acid or saccharin in complex mixtures. Various detection technique can be used (UV, ELSD, LC/MS), based on mobile phase selection.

Condition
Column Primesep C, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer Na2HPO4
Flow Rate 0.25 ml/min
Detection UV, 210 nm
 

Description
Class of Compounds Acid, Hydrophilic, Ionizable
Analyzing Compounds Alginic acid, Citric acid, Benzoic acid, Saccharin
 
Application Analytes:

Alginic Acid
Benzoic Acid
Citric Acid
Saccharin
HPLC Analysis of Alginic Acid in Heartburn Tablets
Alginic acid is a linear copolymer with homopolymeric blocks of (1-4)-linked ?-D-mannuronate (M) and its C-5 epimer ?-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. The monomers can appear in homopolymeric blocks of consecutive G-residues (G-blocks), consecutive M-residues (M-blocks), alternating M and G-residues (MG-blocks), or randomly organized blocks. Molecular weight varies from 10,000 to 600,000. Analysis is a challenging task due to a wide distribution of molecular weights. Alginic acid analyzed in ion-exclusion and size exclusion mode on Primesep C mixed-mode cation exchange column. Alginic acid elutes before void as a single peak with good symmetry. Method can be used for quantitation of alginic acid in various formulation. Low UV or ELSD can be employed.
Application Analytes:

Alginic Acid