Guanosine Diphosphate Mannose

CAS Number 3123-67-9
Molecular Formula C16H25N5O16P2
Molecular Weight 605.343 g/mol
LogP -7.1
  • Diphosphate Mannose, Guanosine
  • Diphosphomannose, Guanosine
  • GDP Mannose
  • Guanosine Diphosphate Mannose
  • Guanosine Diphosphomannose
  • Guanosine Pyrophosphate Mannose
  • Mannose, GDP
  • Mannose, Guanosine Diphosphate
  • Mannose, Guanosine Pyrophosphate
  • Pyrophosphate Mannose, Guanosine


Separation of Guanosine Diphosphate Mannose and Guanosine Diphosphate Fucose in Mixed-Mode Chromatography
Two nucleotides containing different sugar fragments were separated on Primesep SB mixed-mode HPLC column using LC/MS compatible conditions. Method can be used for analysis and isolation of guanosine diphosphate mannose and guanosine diphosphate fucose. Mechanism of retention is weak reversed-phase and strong anion-exchange. retention is controlled by buffer concentration and buffer pH. Both compounds exhibit strong interaction providing good retention and separation.


Column Primesep SB, 4.6x50 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 20/80%
Buffer AmFm pH 2.9- 50 mM
Flow Rate 1.0 ml/min
Detection UV, 250 nm


Class of Compounds Hydrophilic, Ionizable,  Nucleotide sugar
Analyzing Compounds Diphosphate Mannose, Guanosine Diphosphate Fucose

Application Analytes:

Guanosine Diphosphate Fucose
Guanosine Diphosphate Mannose