Polysorbate 80

Molecular Formula C32H60O10
Molecular Weight 604.822 g/mol
InChI Key HDTIFOGXOGLRCB-MDZDMXLPSA-N
LogP 4.8
Synonyms
  • Tween 80
  • Glycol (polysorbate 80)
  • Polyoxyethylene sorbitan oleate
  • Polyethylene oxide sorbitan mono-oleate
  • Polyoxyethylene (20) sorbitan monooleate
  • AC1NQZCF
  • Tween 80 (TN)
  • Polysorbate 80 B.P.C.
  • UNII-6OZP39ZG8H
  • Polysorbate 80, U.S.P.
  • Polysorbate 80 (JP17/NF/INN)
  • Sorbitan, monooleate polyoxyethylene deriv.
  • C11625
  • D01067
  • Sorbitan, mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.
  • 1340-85-8
  • 141927-23-3
  • 178631-96-4
  • 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate
  • 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl(e)-octadec-9-enoate

Applications:


HPLC Retention of Polysorbate on Primesep D Column



Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids. Surfactants that are esters of plain (non-PEG-ylated) sorbitan with fatty acids are usually referred to by the name Span. It is often required to quantitate Polysorbate (Polysorbate/Tween 20, Polysorbate/Tween 40, Polysorbate 60/Tween 60 and Polysorbate 80) by HPLC in various formulations. Polysorbates exist in form of oligomers. All oligomers are separated on Primesep D HPLC column. One of the oligomers can be used in quantitating polysorbate in various drug and food formulations.



Application Analytes:

Polysorbate
Polysorbate 20
Polysorbate 80

HPLC Analysis of Polysorbate in Mixture with Amino Acids and Sugar


Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids. Surfactants that are esters of plain (non-PEG-ylated) sorbitan with fatty acids are usually referred to by the name Span. It is often required to quantitate Polysorbate (Polysorbate/Tween 20, Polysorbate/Tween 40, Polysorbate 60/Tween 60 and Polysorbate 80) by HPLC in various formulations. Polysorbates exist in form of oligomers.

Application Analytes:

Amino Acids
Glycine
Histidine
Polysorbate
Polysorbate 20
Polysorbate 80
Sucrose
Tween 20
Tween 80