S-Adenosyl-L-methionine

CAS Number 29908-03-0
Molecular Formula C15H22N6O5S
Molecular Weight 398.440 g/mol
InChI Key MEFKEPWMEQBLKI-AIRLBKTGSA-N
LogP -1.73
Synonyms
  • S-Adenosylmethionine
  • (2S)-2-Amino-4-[{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(methyl)sulfaniumyl]butanoate (non-preferred name)
  • 29908-03-0
  • S-Adenosylmethionine inner salt
  • AdoMet
  • S Amet
  • SAH (S-Adenosylmethionine)
  • SAM
  • SAMe
  • Transmetil
  • Adenosine, 5'-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-, inner salt
  • (3S)-5'-[(3-amino-3-carboxilatopropil)metilsulfonio]-5'-desoxiadenosina
  • (3S)-5'-[(3-Amino-3-carboxylatopropyl)methylsulfonio]-5'-desoxyadenosin
  • (3S)-5'-[(3-amino-3-carboxylatopropyl)methylsulfonio]-5'-desoxyadenosine
  • (3S)-5'-[(3-amino-3-carboxylatopropyl)methylsulphonio]-5'-deoxyadenosine
  • Active methionine
  • Ademetionine
  • Adenosine, 5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxy-, hydroxide, inner salt, (3S)-
  • Adenosine, 5'-[(L-3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxy-, hydroxide, inner salt
  • Donamet
  • L-Methionine, S-adenosyl-
  • L-S-Adenosylmethionine
  • Methionine, S-adenosyl-
  • S-Adenosyl-L-methionine
  • Adenosylmethionine
  • EINECS 249-946-8
  • Methioninyladenylate
  • UNII-7LP2MPO46S
  • S-adenosyl-L-methioninate
  • 23095-97-8
  • 2613-02-7
  • 28378-99-6
  • 5134-37-2
  • 86522-35-2
  • 86866-89-9

Applications:


HPLC Separation of 2-HEP and 2-HPP in the Presence of Methylcobalamin and Amino Acids
chr_292.gif Methylcobalamin, S-Adenosyl-L-methionine, 2-hydroxyethyl phosphonic acid, and 2-hydroxy propyl phosphonic acid were separated in reversed-phase anion-exchange mixed-mode on a Primesep SB HPLC column. Compounds are monitored by UV and ELSD. Method is compatible with LC/MS. Selectivity of separation is controlled by varying the amount of ACn buffer pH and buffer concentration.

Condition

Column Primesep SB, 4,6x150 mm, 5 µm, 100A
Mobile Phase MeCN - 20%
Buffer AmFm
Flow Rate 1.0 ml/min
Detection ELSD 35C,  UV 250nm
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Description

Class of Compounds  Acid,  Hydrophilic, Ionizable
Analyzing Compounds S- Adenosyl- L- methionine, Methylcobalamin, 2-hydroxyethylphosphonic acid, 2-hydroxypropylphosphonic acid


Application Analytes:

2-hydroxyethyl phosphonic acid
2-hydroxypropyl phosphonic acid
Methylcobalamin
S-Adenosyl-L-methionine